Evaluation of HGV Viremia Prevalence and Its Co-Infection with HBV, HCV, HIV and HTLV-1 in Hemophilic Patients of Southern Khorassan, Iran

Masood Ziaee; Asghar Zarban; Peyman Malekinejad; Hadi Akhbary

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Evaluation of HGV Viremia Prevalence and Its Co-Infection with HBV, HCV, HIV and HTLV-1 in Hemophilic Patients of Southern Khorassan, Iran

Author(s):

Masood Ziaee^1,*,

Asghar Zarban²,

Peyman Malekinejad³,

Hadi Akhbary⁴

1Infectious Diseases, Birjand University of Medical Sciences, Birjand, Iran

2Clinical Biochemistry, Birjand University of Medical Sciences, Birjand, Iran

3General Practitioner, Birjand University of Medical Sciences, Birjand, Iran

4Rheumatology, Birjand University of Medical Sciences, Birjand, Iran

Hepatitis Monthly:Vol. 7, issue 1; 11-14

Published online:Feb 01, 2007

Article type:Research Article

Received:Feb 15, 2006

Accepted:Oct 02, 2006

How to Cite:Ziaee M, Zarban A, Malekinejad P, Akhbary H. Evaluation of HGV Viremia Prevalence and Its Co-Infection with HBV, HCV, HIV and HTLV-1 in Hemophilic Patients of Southern Khorassan, Iran.Hepat Mon.2007;7(1):11-14.

Abstract

Background and Aims: The GB virus-C (GBV-C) and Hepatitis G virus (HGV), collectively known as GBV-C/HGV and
transmitted through blood transfusion and blood components. A co-infection of HGV and HCV is often seen in patients
with hemophilia. The paucity of information about rate of GBV-C infection among hemophilic patients in Iran promoted
the current study.
Methods: This study was performed on 80 hemophilic patients from south Khorassan branch of Iranian hemophilia
society in Birjand. All 80 serum samples were tested for hepatitis B surface antigen (HBs-Ag), Anti HCV, Anti HIV, and
Anti HTLV-1. All sera positive for HCVAb were retested by recombinant immunoblot assay as a complementary test. Also,
Serum HCV-RNA, HCV genotyping and HGV-RNA were detected.
Results: The prevalence of HGV-RNA was 5% (4 of 80). The prevalence of Anti HCV positive was 26.3% (21 of 80) and
HCV- RNA was detected in 80% (17 of 21) of these patients. Co infection of HGV with HCV was 5%. HBsAg and Anti
HIV were negative in all of our patients. Anti HTLV-1 was detected in one patient (1.25%).
Conclusions: HGV and HCV are prevalent in South Khorassan hemophilic patients. Prevalence of HGV infection is less
than HCV but it is more prevalent than HBV, HIV and HTLV-1 infection.

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Author(s):

Masood Ziaee:[PubMed][Scholar]
Asghar Zarban:[PubMed][Scholar]
Peyman Malekinejad:[PubMed][Scholar]
Hadi Akhbary:[PubMed][Scholar]