Single Nucleotide Polymorphisms of DNA Methyltransferase 1 Gene and Gastric Cancer in Iranian Patients: a Case Control Study

Fatemeh Khatami; B Noorinayer; S Ghiasi; R Mohebi; M Hashemi; MR Zali

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Abstract
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Single Nucleotide Polymorphisms of DNA Methyltransferase 1 Gene and Gastric Cancer in Iranian Patients: a Case Control Study

Author(s):

Fatemeh Khatami^1,*,

B Noorinayer¹,

S Ghiasi¹,

R Mohebi²,

M Hashemi³,

MR Zali¹

1Research Center for Gastrointestinal and Liver Disease, Shahid Beheshti University (MC), Taleghani Hospital, Iran

2Iran

3Associate Professor of pathology. Imam Hossein Hospital, Iran

International Journal of Cancer Management:Vol. 1, issue 3; e80455

Published online:Sep 30, 2008

Article type:Research Article

Received:Sep 30, 2008

Accepted:Sep 30, 2008

How to Cite:Fatemeh KhatamiB NoorinayerS GhiasiR MohebiM HashemiMR Zaliet al.Single Nucleotide Polymorphisms of DNA Methyltransferase 1 Gene and Gastric Cancer in Iranian Patients: a Case Control Study.Int J Cancer Manag.1(3):e80455.

Abstract

Background: Gastric cancer is one of the most common malignant tumors in Iran. Hypomethylation and/or hypermethylation of DNA have been described in Gastric cancer and is presumed to be an early event in this process. Objective: We hypothesized that Single nucleotide polymorphisms of DNMT1 gene may be associated with the genetic susceptibility to Gastric cancer.

Methods: 200 patients and 200 controls, both with Iranian origin were studied. Three polymorphisms were genotyped by PCR-RFLP. Allele frequencies and genotypes were compared between the cases and controls. Odds ratios were calculated and the interaction between polymorphisms, age and sex were examined.

Results: There was no significant association between DNMT1 polymorphisms and Gastric cancer.

Conclusion: We could not show any association between DNMT1 polymorphisms and gastric cancer. Larger sets of polymorphisms and sample sizes are required to test the possibility of association between polymorphisms of this gene and gastric cancer

Keywords

single nucleotide polymorphisms (SNPs)

DNA methyltransferase 1 (DNMT1)

gastric cancer (GC)

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