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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
The PrognosticRole of Tumor Marker CA-125 in B-Cell
Authors
Bahram Memar1, Seyed Amir Aledavood2,*, Soodabeh Shahidsales2, Mitr Ahadi3, Mahdi Farzadnia4, Hamid Reza Raziee2, Sedighe Noori5, Naser Tayebi-Meybodi4, Sakineh Amouian4, Samira Mohtashami2
1Surgical Oncology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Dept. of Internal, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Dept. of Pathology, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Medical Student, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding Author: Corresponding author: Seyed Amir Aledavood, Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Tel: +98-38461518, E-mail: Email: [email protected]
Published online:Feb 28, 2015
Article type:Research Article
Received:May 01, 2014
Accepted:Oct 25, 2014
How to Cite:Memar B, Aledavood SA, Shahidsales S, Ahadi M, Farzadnia M, et al. The PrognosticRole of Tumor Marker CA-125 in B-Cell. Int J Cancer Manag. 2015;8(1):e80580. doi:
Abstract
Background: B-cell non-Hodgkin’s lymphoma (NHL) is a common malignancy of lymphoid tissues. Different types of NHL show various behaviors, prognoses, and responses to treatment. Evaluation of disease activity in NHL can be helpful in managing and even increasing the patient’s survey.
Methods and Results: In total, 121 patients (76 males and 45 females), and their age range were 18-53 years, were evaluated in this study. The mean level of serum carbohydrate antigen 125 (CA-125) was 89.3±18.5 u/ml, ranging from 27 to 135 u/ml. There were significant differences in International Prognostic Index (IPI) score (p=0.002), stage of the disease (p=0.006), mortality rate (p=0.02), and relapse rate (p=0.04) between patients with serum CA-125 level 35 u/ml.
Conclusion: CA-125 seems to be a useful and reliable tumor marker for monitoring a patient with NHL. It might be the time to consider CA-125 in staging, prognostic scoring, or decision making about NHL treatment.
Highlights
Copyright
© 2015, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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