Pulmonary Hypertension and Its Determinants in Beta-thalassemia Major and Intermedia Considering Left Ventricular Functional Stat

authors:

avatar Behzad Farahani 1 , avatar Abbas Fadaii 2 , avatar Isa Khaheshi 3 , avatar Forooz Baktash 4 , avatar Mohammad Amin Abbasi 5 , * , avatar Ronak Mohammadi 6 , avatar Koosha Paydary 7

Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
Department of Internal Medicine, Labafi Nejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences (IUMS) Tehran, Iran
Students' Scientific Research Center (SSRC), Tehran University of Medic

how to cite: Farahani B, Fadaii A, Khaheshi I , Baktash F, Abbasi M A , et al. Pulmonary Hypertension and Its Determinants in Beta-thalassemia Major and Intermedia Considering Left Ventricular Functional Stat. Int J Cardio Pract. 2016;1(1):e130023. doi: 10.20286/ijcp-010107.

Abstract

Introduction: Pulmonary hypertension (PHT) is a common complication in Beta-thalassemia. We aimed to determine the prevalence of PHT and its main indicators in patients with Beta thalassemia Major (TM) and Beta-thalassemia Intermedia (TI), considering left ventricular function.
Methods: Pulmonary hypertension (PHT) is a common complication in Beta-thalassemia. We aimed to determine the prevalence of PHT and its main indicators in patients with Beta thalassemia Major (TM) and Beta-thalassemia Intermedia (TI), considering left ventricular function.
Results: The overall prevalence of PHT in TM and TI group was estimated to be 35.2% and 29.3%, respectively; while reduced LVEF was evident in 22.7% and 10.1% of patients with TM and TI, respectively. No significant correlation was observed between mean PAP and LVEF in the patients with TI (Pearson coefficient = -0.096, P value = 0.345); while, an adverse association was revealed between mean PAP and LVEF in patients with TM (Pearson coefficient = -0.227, P value = 0.033). Upon unte analysis, the only significant association was observed between LVEF and pulmonary hypertension among TM patients (P value = 0.001).Our results did not indicate that male gender and aging may affect the development of PHT.
Conclusions: According to our findings, a considerable proportion of patients with TM and TI may have PHT. We detected an adverse association between mean PAP and LVEF in patients with TM. Left ventricular function was reduced in patients with PHT among TM group.

Fulltext

Full-text is available in PDF file.

© 2016, Cardiovascular Research Center of Shahid Beheshti University of Medicl Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.