Pulmonary Hypertension and Its Determinants in Beta-thalassemia Major and Intermedia Considering Left Ventricular Functional Stat

Behzad Farahani; Abbas Fadaii; Isa Khaheshi; Forooz Baktash; Mohammad Amin Abbasi; Ronak Mohammadi; Koosha Paydary

doi:10.20286/ijcp-010107

International Journal of Cardiovascular Practice

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https://doi.org/10.20286/ijcp-010107

Pulmonary Hypertension and Its Determinants in Beta-thalassemia Major and Intermedia Considering Left Ventricular Functional Stat

Author(s):

Behzad Farahani¹,

Abbas Fadaii²,

Isa Khaheshi

³,

Forooz Baktash⁴,

Mohammad Amin Abbasi

^5,*,

Ronak Mohammadi¹,

Koosha Paydary⁶

1Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

2Department of Internal Medicine, Labafi Nejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran

5Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran

International Journal of Cardiovascular Practice:Vol. 1, issue 1; 13-15

Published online:Apr 01, 2016

Article type:Research Article

Received:Dec 10, 2015

Accepted:Dec 20, 2015

How to Cite:Behzad FarahaniAbbas FadaiiIsa KhaheshiForooz BaktashMohammad Amin AbbasiRonak MohammadiKoosha Paydaryet al.Pulmonary Hypertension and Its Determinants in Beta-thalassemia Major and Intermedia Considering Left Ventricular Functional Stat.Int J Cardiovasc Pract.2016;1(1):e130023.https://doi.org/10.20286/ijcp-010107.

Abstract

Introduction: Pulmonary hypertension (PHT) is a common complication in Beta-thalassemia. We aimed to determine the prevalence of PHT and its main indicators in patients with Beta thalassemia Major (TM) and Beta-thalassemia Intermedia (TI), considering left ventricular function.

Methods: Pulmonary hypertension (PHT) is a common complication in Beta-thalassemia. We aimed to determine the prevalence of PHT and its main indicators in patients with Beta thalassemia Major (TM) and Beta-thalassemia Intermedia (TI), considering left ventricular function.

Results: The overall prevalence of PHT in TM and TI group was estimated to be 35.2% and 29.3%, respectively; while reduced LVEF was evident in 22.7% and 10.1% of patients with TM and TI, respectively. No significant correlation was observed between mean PAP and LVEF in the patients with TI (Pearson coefficient = -0.096, P value = 0.345); while, an adverse association was revealed between mean PAP and LVEF in patients with TM (Pearson coefficient = -0.227, P value = 0.033). Upon unte analysis, the only significant association was observed between LVEF and pulmonary hypertension among TM patients (P value = 0.001).Our results did not indicate that male gender and aging may affect the development of PHT.

Conclusions: According to our findings, a considerable proportion of patients with TM and TI may have PHT. We detected an adverse association between mean PAP and LVEF in patients with TM. Left ventricular function was reduced in patients with PHT among TM group.

Keywords

Hypertension

Pulmonary beta-Thalassemia Ventricular Function

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Author(s):

Behzad Farahani:[PubMed][Scholar]
Abbas Fadaii:[PubMed][Scholar]
Isa Khaheshi:[PubMed][Scholar]
Forooz Baktash:[PubMed][Scholar]
Mohammad Amin Abbasi:[PubMed][Scholar]
Ronak Mohammadi:[PubMed][Scholar]
Koosha Paydary:[PubMed][Scholar]