Updates on Advanced Therapies for Acute Pulmonary Embolism


avatar Bavand Bikdeli 1 , 2 , avatar Behnood Bikdeli 3 , 4 , *

Division of Medical Subspecialties, Lyell McEwin Hospital, Adelaide, Australia
School of Medicine, University of Adelaide, Adelaide, Australia
Center for Outcomes Research and Evaluation, Yale University School of Medicine, New Haven, USA
Division of Cardiology, Columbia University Medical Center, New York, United States

how to cite: Bikdeli B, Bikdeli B . Updates on Advanced Therapies for Acute Pulmonary Embolism. Int J Cardiovasc Pract. 2016;1(3):e130051. https://doi.org/10.21859/ijcp-010301.


Venous thromboembolism is the third common vascular disease after acute myocardial infarction and stroke, and acute pulmonary embolism (PE) remains as the most common preventable cause of in-hospital mortality. In addition to routine anticoagulant therapy, several advanced treatment options have been introduced over the past three decades. We provide a succinct and contemporary summary of the evidence base and important indications for inferior vena caval filter placement, systemic and catheter-based thrombolytic therapy, as well as percutaneous and surgical thrombectomy. Appropriate case selection for advance therapies for PE could minimize the adverse effects and costs, while optimizing the outcomes.


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