Thrombotic and Thromboembolic Complications in Patients with Adult Congenital Heart Disease


avatar Behnood Bikdeli 1 , 2 , * , avatar Phillip Green 1 , avatar Matthew J. Lewis 1 , avatar Marlon S. Rosenbaum 1

Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York-Presbyterian Hospital, New York, USA
Center for Outcomes Research and Evaluation, Yale University School of Medicine, New Haven, USA

how to cite: Bikdeli B , Green P, J. Lewis M, S. Rosenbaum M. Thrombotic and Thromboembolic Complications in Patients with Adult Congenital Heart Disease. Int J Cardio Pract. 2017;2(2):e130063. doi: 10.21859/ijcp-020201.


Improved medical and surgical interventions have increased the longevity of patients with congenital heart defects and most such patients live into adulthood. Thrombotic and thromboembolic complications constitute a major cause of mortality and morbidity in patients with adult congenital heart disease (ACHD). Such events include acute coronary syndromes, ischemic stroke (cardioembolic due to thrombus formation in the systemic ventricle, secondary to atrial arrhythmias, or due to paradoxical embolism), and venous thromboembolism. Some thrombotic phenomena are also specific to patients with ACHD, such as those related to Fontan circulation. We provide a succinct overview of thrombotic and thromboembolic complications in patients with ACHD, focusing on stroke and venous thromboembolic events.


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© 2017, Cardiovascular Research Center of Shahid Beheshti University of Medicl Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.