Biological Pacemakers - A Review


avatar Velvizhi Gunasekaran 1 , * , avatar Raja Selvaraj 2

Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry, India
Department of Cardiology, Jawaharlal Institute of Postgraduate Medicine and Research, Puducherry, India

how to cite: Gunasekaran V, Selvaraj R . Biological Pacemakers - A Review. Int J Cardio Pract. 2018;3(1):e130258. doi: 10.21859/ijcp-03103.


Slow heart rates, due to sinus node disease or atrioventricular conduction block, are a significant problem for many patients. Currently, these patients are treated with electronic pacemakers, which provide effective therapy, but are also associated with many problems. Use of biological pacemakers is an attractive solution to these problems. Approaches for the creation of such pacemakers include either the injection of cells that have pacemaker activity (cell-based approach) or modification of cells in the heart to induce pacemaker activity by delivering genes (gene-based approach). This article reviews the progress in the development of biological pacemakers.


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© 2018, Cardiovascular Research Center of Shahid Beheshti University of Medicl Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.