Predictive Implications of Serum Lipid Metabolism over Time in Intensive Care Unit Admitted Patients

Mehdi Motafaker Azad; Mohammad Amin Abbasi; Niloofar Basharzad; Abbas Fadaii

doi:10.21859/ijcp-03205

International Journal of Cardiovascular Practice

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https://doi.org/10.21859/ijcp-03205

Predictive Implications of Serum Lipid Metabolism over Time in Intensive Care Unit Admitted Patients

Author(s):

Mehdi Motafaker Azad¹,

Mohammad Amin Abbasi²,

Niloofar Basharzad¹,

Abbas Fadaii^1,*

1Department of Pulmonology and Intensive Care Medicine, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Department of medicine, firoozabadi hospital, Iran University of Medical Sciences, Tehran, Iran

International Journal of Cardiovascular Practice:Vol. 3, issue 2; 38-42

Published online:Apr 18, 2018

Article type:Research Article

Received:Mar 11, 2018

Accepted:Mar 27, 2018

How to Cite:Mehdi Motafaker AzadMohammad Amin AbbasiNiloofar BasharzadAbbas FadaiiPredictive Implications of Serum Lipid Metabolism over Time in Intensive Care Unit Admitted Patients.Int J Cardiovasc Pract.3(2):e130265.https://doi.org/10.21859/ijcp-03205.

Abstract

Introduction: Serum lipoprotein levels change during hospitalization and effect patient’s outcome in case of sepsis. The aim of this study was to investigate the prognostic values of the serum levels of lipids in Intensive Care Unit (ICU) admitted patients.

Methods: Intensive Care Unit admitted patients with various etiologies were enrolled in this study. Serum lipid level was collected on the first and seventh day of admission. Clinical outcome and baseline characteristics, including age, gender, cause of admission, length of ICU stay, and discharge or death were monitored prospectively in a short cohort.

Results: A total of 108 patients were enrolled in this study. The overall mortality rate was 45%. The average duration of hospitalization at the ICU was significantly lengthier in the un-survived group. Lipid profile had a similar pattern in both genders. Triglyceride level seemed to increase from Day one to Day seven. These changes were observed in both unsurvived and survived group and were not significantly different. A considerable decline of 24% in High Density Lipoprotein (HDL) was detected among unsurvived patients. The mean value of TG on day seven among unsurvived patients was significantly higher than that of the survived group. Receiver Operating Characteristic (ROC) curve illustrated the higher diagnostic ability of HDL level in comparison with other parameters. On day seven, serum HDL cutoff value of 32 (sensitivity 75%; specificity 60%) was observed for predicting the mortality.

Conclusions: Cholesterol is essential for integrity as well as the function of the cell membrane, therefore, dyslipidemia occurring during hospitalization may negatively influence the outcome. Consequently, changes in lipid profile could be a prognostic biomarker for predicting mortality in ICU-admitted patients.

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Author(s):

Mehdi Motafaker Azad:[PubMed][Scholar]
Mohammad Amin Abbasi:[PubMed][Scholar]
Niloofar Basharzad:[PubMed][Scholar]
Abbas Fadaii:[PubMed][Scholar]