Comparison of Serum Levels of Vitamin D in Patients With and Without Acute Coronary Syndrome

Reza Hassanzadeh Makoui; Mahsa Soltannejad Dizaji; Hamid Khederlou

doi:10.21859/ijcp-03201

International Journal of Cardiovascular Practice

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https://doi.org/10.21859/ijcp-03201

Comparison of Serum Levels of Vitamin D in Patients With and Without Acute Coronary Syndrome

Author(s):

Reza Hassanzadeh Makoui¹,

Mahsa Soltannejad Dizaji²,

Hamid Khederlou

^3,*

1Department of Cardiology, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

2Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

3Student Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

International Journal of Cardiovascular Practice:Vol. 3, issue 2; 25-29

Published online:Apr 18, 2018

Article type:Research Article

Received:Dec 27, 2017

Accepted:Oct 06, 2018

How to Cite:Reza Hassanzadeh MakouiMahsa Soltannejad DizajiHamid KhederlouComparison of Serum Levels of Vitamin D in Patients With and Without Acute Coronary Syndrome.Int J Cardiovasc Pract.3(2):e130281.https://doi.org/10.21859/ijcp-03201.

Abstract

Introduction: Coronary artery disease is one of the most common causes of mortality around the world. The association between vitamin D deficiency and the incidence of diseases, such as hypertension, diabetes, and metabolic syndrome, has been demonstrated previously. There have been studies concerning the relationship between vitamin D deficiency and cardiovascular diseases, which have shown different results. Therefore, this study aimed at determining the association between serum levels of vitamin D and acute coronary syndrome

. Methods: In this case-control study, serum levels of vitamin D were compared between 50 patients with acute coronary syndrome and 50 individuals without this syndrome. A checklist, including demographic data of patients, comorbidities, vitamin D levels, lipid profiles, Electrocardiogram (ECG) changes and echocardiography

results, was completed during hospitalization. Results: Mean age in the case and control group was 63.26 ± 10.76 and 61.22 ± 10.71 years, respectively. The prevalence of diabetes and high blood pressure in the case group was 32% and 54% versus 10% and 8% in the control group, respectively. Overall, 70% and 18% of subjects were smokers in the control and case groups, respectively. Mean concentration of vitamin D in serum was 20.63 ± 13.90 ng/mL, which was significantly lower than the control group with a mean concentration of 29.54 ± 16.8 ng/mL (P-Value = 0.002). Finally, it was shown that for every one unit increase in vitamin D levels, the risk of acute coronary syndrome was reduced by 7% (P-Value = 0.005).

Conclusions: The results of this study showed that the serum levels of vitamin D were significantly lower in patients with acute coronary syndrome compared to those without this disease.

Keywords

Acute Coronary Syndrome

Vitamin D

Arrhythmias

Cardiac

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Author(s):

Reza Hassanzadeh Makoui:[PubMed][Scholar]
Mahsa Soltannejad Dizaji:[PubMed][Scholar]
Hamid Khederlou:[PubMed][Scholar]