Comparison of Serum Levels of Vitamin D in Patients With and Without Acute Coronary Syndrome

authors:

avatar Reza Hassanzadeh Makoui 1 , avatar Mahsa Soltannejad Dizaji 2 , avatar Hamid Khederlou ORCID 3 , *

Department of Cardiology, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
Student Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

how to cite: Hassanzadeh Makoui R, Soltannejad Dizaji M, Khederlou H. Comparison of Serum Levels of Vitamin D in Patients With and Without Acute Coronary Syndrome. Int J Cardio Pract. 2018;3(2):e130281. doi: 10.21859/ijcp-03201.

Abstract

Introduction: Coronary artery disease is one of the most common causes of mortality around the world. The association between vitamin D deficiency and the incidence of diseases, such as hypertension, diabetes, and metabolic syndrome, has been demonstrated previously. There have been studies concerning the relationship between vitamin D deficiency and cardiovascular diseases, which have shown different results. Therefore, this study aimed at determining the association between serum levels of vitamin D and acute coronary syndrome
. Methods: In this case-control study, serum levels of vitamin D were compared between 50 patients with acute coronary syndrome and 50 individuals without this syndrome. A checklist, including demographic data of patients, comorbidities, vitamin D levels, lipid profiles, Electrocardiogram (ECG) changes and echocardiography
results, was completed during hospitalization. Results: Mean age in the case and control group was 63.26 ± 10.76 and 61.22 ± 10.71 years, respectively. The prevalence of diabetes and high blood pressure in the case group was 32% and 54% versus 10% and 8% in the control group, respectively. Overall, 70% and 18% of subjects were smokers in the control and case groups, respectively. Mean concentration of vitamin D in serum was 20.63 ± 13.90 ng/mL, which was significantly lower than the control group with a mean concentration of 29.54 ± 16.8 ng/mL (P-Value = 0.002). Finally, it was shown that for every one unit increase in vitamin D levels, the risk of acute coronary syndrome was reduced by 7% (P-Value = 0.005).
Conclusions: The results of this study showed that the serum levels of vitamin D were significantly lower in patients with acute coronary syndrome compared to those without this disease.

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© 2018, Cardiovascular Research Center of Shahid Beheshti University of Medicl Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.