Association of Serum Vitamin D Level and Serum Lipids Profile


avatar Roxana Sadeghi 1 , avatar Mohammad Reza Eidi 1 , avatar Nasim Zamani 2 , *

Cardiovascular Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

how to cite: Sadeghi R, Eidi M R, Zamani N. Association of Serum Vitamin D Level and Serum Lipids Profile. Int J Cardio Pract. 2018;3(2):e130282. doi: 10.21859/ijcp-03203.


Introduction: High level of vitamin D is associated with a better health status. The role of vitamin D deficiency in the incidence of cardiovascular events is demonstrated in previous studies. The current study aimed at evaluating the effect of vitamin D supplement therapy on serum lipids profile, as a risk factor for cardiovascular diseases.
Methods: The current prospective cohort study included 221 patients admitted to a university hospital from March 2014 to March 2015. The baseline levels of the patients′ serum vitamin D and lipid profile of the study subjects were recorded. After three months treatment with vitamin D, the patients′ serum vitamin D level and lipid profile were reevaluated. The results before and after the supplement therapy were compared using statistical methods.
Results: The mean age of the patients was 48.2 ± 14.0 years. The mean vitamin D level was 21.0 ± 16.6 ng/mL at baseline, which increased to 35.8 ± 32.7 ng/mL (P = 0.001) after a three-month vitamin D supplement therapy. Mean low-density lipoprotein (LDL) decreased from 112.1 ± 30.0 to 98.7 ± 31.7 mg/dL (P = 0.003) after the supplement therapy. Mean high-density lipoprotein (HDL) increased from 42.8 ± 11.2 to 44.5 ± 9.0 mg/dL, but the difference was insignificant before and after the treatment (P = 0.2). Mean cholesterol reduced from 183.8 ± 42.3 to 169.5 ± 41.9 mg/dL (P = 0.02) and the mean TG dropped from 147.5 ± 98.7 to 134.7 ± 71.1 mg/dL, (P = 0.1) after vitamin D intake.
Conclusions: The mean levels of LDL and cholesterol significantly decreased during the three-month intervention; in addition, although some changes were observed in the level of HDL and TG, the differences were statistically insignificant. Further studies on larger sample sizes and longer follow-ups are recommended.


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