9P21.3 locus; An Important Region in Coronary Artery Disease: A Panel Approach to Investigation of the Coronary Artery Disease Etiology

Soodeh Omidi; Fatemeh Ebrahimzadeh; Samira Kalayinia

doi:10.29252/ijcp-25001

International Journal of Cardiovascular Practice

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

Authors Guide Submit Manuscript

https://doi.org/10.29252/ijcp-25001

9P21.3 locus; An Important Region in Coronary Artery Disease: A Panel Approach to Investigation of the Coronary Artery Disease Etiology

Author(s):

Soodeh Omidi¹,

Fatemeh Ebrahimzadeh²,

Samira Kalayinia^3,*

1Department of Genetic, Faculty of Advanced Medical Technologies, Golestan University of Medical Science (GUMS), Gorgan, Iran

2Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran

3Cardiogenetics Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

International Journal of Cardiovascular Practice:Vol. 4, issue 2; 21-35

Published online:May 07, 2019

Article type:Review Article

Received:Apr 07, 2019

Accepted:May 06, 2019

How to Cite:Soodeh OmidiFatemeh EbrahimzadehSamira Kalayinia9P21.3 locus; An Important Region in Coronary Artery Disease: A Panel Approach to Investigation of the Coronary Artery Disease Etiology.Int J Cardiovasc Pract.4(2):e130551.https://doi.org/10.29252/ijcp-25001.

Abstract

Coronary artery disease (CAD) is a disease of major concern worldwide. It is the main cause of mortality in many societies and improving the understanding about the CAD mechanism, progression and treatment, is necessary. Recent discovery of genetic factors underlying CAD has improved our knowledge of the disease in support of well-known traditional risk factors. Genotype-environment interaction is known as the main risk factor. Loci on many different chromosomes have been identified as a risk factors that increase CAD susceptibility. Here we performed a comprehensive literature review pinpointing hotspot loci involved in CAD pathogenicity. The 9p21.3 locus is the most common region associated with CAD and its specific structure and function have been remarkable in many studies. Moreover, the variations in the 9p21.3 locus have been implicated in CAD patients in different populations around the world. According to conclusions from this the 9p21.3 locus can be the first point of focus in etiology investigations of CAD patients.

Keywords

Etiology

Heart Disease

Genome Wide Association

Study

Fulltext

Full-text is available in PDF file.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Soodeh Omidi:[PubMed][Scholar]
Fatemeh Ebrahimzadeh:[PubMed][Scholar]
Samira Kalayinia:[PubMed][Scholar]