Different Polymorphisms of Placental Growth Factor (PLGF) Gene in Iranian Women's Population with Pre-eclampsia

Parisa Pourroostaei Ardakani; Arezo Ramezani; Zeinab  Piravar; Nastaran Asgharimoghaddam; Roudabeh Behzadi; Mehrdad Jafari Fesharaki

doi:10.29252/ijcp-26694

International Journal of Cardiovascular Practice

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https://doi.org/10.29252/ijcp-26694

Different Polymorphisms of Placental Growth Factor (PLGF) Gene in Iranian Women's Population with Pre-eclampsia

Author(s):

Parisa Pourroostaei Ardakani¹,

Arezo Ramezani¹,

Zeinab Piravar ^1,*,

Nastaran Asgharimoghaddam¹,

Roudabeh Behzadi¹,

Mehrdad Jafari Fesharaki²

1Department of Biology, Faculty of Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran

2School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

International Journal of Cardiovascular Practice:Vol. 4, issue 4; 111-116

Published online:Dec 05, 2019

Article type:Research Article

Received:Aug 10, 2019

Accepted:Nov 05, 2019

How to Cite:Parisa Pourroostaei ArdakaniArezo RamezaniZeinab Piravar Nastaran AsgharimoghaddamRoudabeh BehzadiMehrdad Jafari Fesharakiet al.Different Polymorphisms of Placental Growth Factor (PLGF) Gene in Iranian Women's Population with Pre-eclampsia.Int J Cardiovasc Pract.4(4):e130568.https://doi.org/10.29252/ijcp-26694.

Abstract

Introduction: Preeclampsia is a complication affecting pregnant women worldwide, which leads to maternal and fetal morbidity and mortality. Due to the importance of mutations in the PLGF (Placental Growth Factor) gene and the association with the incidence of preeclampsia, this study aimed to evaluate the association of polymorphisms of the PLGF gene with the prevalence of preeclampsia in Iranian women.

Methods: Fifty pregnant women with pre-eclampsia diagnosis and 50 healthy pregnant women for determination of genotypes rs1464547123, rs12411, rs1399853427, and rs1312670436 were evaluated using the Sanger sequencing method.

Results: There was no significant difference in the frequency of alleles ofrs1464547123, rs1399853427 and rs1312670436 polymorphisms between case and control groups (P > 0.05), but the rate of recessive allele A in rs12411 polymorphism was significantly higher in the case group than in the control group (case = 24%, control = 8%, P-Value = 0.04), while the frequency of the allele T in the control group was higher than that of the patient group (case = 76%, control = 92%, P-Value = 0.04) The frequency of AT genotype in the patient group was a none significantly higher than the control group (case = 8%, control = 4%, P-Value = 0.1) and the frequency of AA genotypes in the case group was none significantly higher than that of the control group (case = 16%, control = 4%, P-Value = 0.1).

Conclusions: The results revealed that polymorphism rs12411 of the gene encoding PLGF has a significant difference among individuals with and without pre-eclampsia and can affect the incidence of pre-eclampsia among Iranian women.

Keywords

Placenta Growth Factor

Pre-Eclampsia

Polymorphism

Genetic

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Author(s):

Parisa Pourroostaei Ardakani:[PubMed][Scholar]
Arezo Ramezani:[PubMed][Scholar]
Zeinab Piravar :[PubMed][Scholar]
Nastaran Asgharimoghaddam:[PubMed][Scholar]
Roudabeh Behzadi:[PubMed][Scholar]
Mehrdad Jafari Fesharaki:[PubMed][Scholar]