The Association of Serum Vitamin D Levels and Short Term and 6-month Outcomes among Patients with Acute Coronary Syndrome

authors:

avatar Mohsen Asadi Qomi 1 , avatar Sepehr Gohari 2 , avatar Hassan Ahangar 1 , * , avatar Ahmad Jalilvand 3 , avatar Seyed Jamal Moosavi 4 , avatar Koorosh Kamali 5 , avatar Mohammad Masoud Vakili 5 , avatar Tara Reshadmanesh 2

Department of Cardiology, Mousavi Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Department of Pathology, Mousavi Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Department of Biostatistics, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

how to cite: Asadi Qomi M, Gohari S, Ahangar H , Jalilvand A, Moosavi S J, et al. The Association of Serum Vitamin D Levels and Short Term and 6-month Outcomes among Patients with Acute Coronary Syndrome. Int J Cardio Pract. 2020;5(2):e131483. doi: 10.5812/ijcp-131483.

Abstract

Introduction: vitamin D affects the function of most of the cells in the body, including myocytes and endothelial cells, and also affects platelet function. This study aims to evaluate the relation between vitamin D deficiency and in-hospital and 6-month outcomes of patients with the acute coronary syndrome.
Methods: This was a prospective cohort study of patients admitted to Mousavi hospital with the diagnosis of acute coronary syndrome. A venous blood sample obtained from patients at the time of admission and 25-hydroxyvitamin D, lipid profile, and hstroponin-I levels were measured. After coronary angiography, the severity of the coronary artery stenosis was calculated by the syntax score. Patients also evaluated inhospital outcomes and even followed up for 6-month results.
Results: Totally, 204 patients were included in the study. The mean ± SD of age was 60 ± 11.6-year-old. The overall vitamin D deficiency was 80.9%. There was no association between vitamin D deficiency and in-hospital and 6-month mortality in patients with acute coronary syndrome (P = 0.824). There was a direct and statistically significant association between vitamin D levels and HDL cholesterol (P = 0.011). Twenty-eight percent of patients with negative hs-troponin-I and 14% with positive hs-troponin-I had normal vitamin D levels, which was statistically significant (P = 0.045).
Conclusion: This study does not demonstrate an association between vitamin D levels and in-hospital and 6-month outcomes in patients with the acute coronary syndrome.

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