Clinical profile of patients with prosthetic heart valve thrombosis undergoing fibrinolytic therapy and NYHA class as a predictor of outcome

Sanjeev Bhatia; Sharad Jain; Vishal Sharma; Zeeshan  Mansuri; Krutika Patel; Pragya Jain; Mithilesh Kulkarni; Tanmay Agrawal; Kamal Sharma

doi:10.5812/intjcardiovascpract-131484

International Journal of Cardiovascular Practice

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https://doi.org/10.5812/intjcardiovascpract-131484

Clinical profile of patients with prosthetic heart valve thrombosis undergoing fibrinolytic therapy and NYHA class as a predictor of outcome

Author(s):

Sanjeev Bhatia¹,

Sharad Jain¹,

Vishal Sharma¹,

Zeeshan Mansuri ^1,*,

Krutika Patel²,

Pragya Jain³,

Mithilesh Kulkarni¹,

Tanmay Agrawal¹,

Kamal Sharma¹

1Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India

2Department of Research, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India

3NHL Medical College, VS General Hospital, Paldi, Ahmedabad, Gujarat 380006, Gujarat, India

International Journal of Cardiovascular Practice:Vol. 6, issue 1; e131484

Published online:Oct 30, 2020

Article type:Research Article

Received:Mar 25, 2020

Accepted:Sep 18, 2020

How to Cite:Sanjeev BhatiaSharad JainVishal SharmaZeeshan Mansuri Krutika PatelPragya JainMithilesh KulkarniTanmay AgrawalKamal Sharmaet al.Clinical profile of patients with prosthetic heart valve thrombosis undergoing fibrinolytic therapy and NYHA class as a predictor of outcome.Int J Cardiovasc Pract.2020;6(1):e131484.https://doi.org/10.5812/intjcardiovascpract-131484.

Abstract

Introduction: Prosthetic heart valve thrombosis (PHVT) is a major complication in patients with mechanical prosthetic heart valve which occurs primarily due to ineffective anticoagulation. This study aimed to evaluate the clinical profile of the patients presenting with PHVT undergoing fibrinolytic therapy and analyzing patients with respect to New York Heart Association (NYHA) functional class on presentation and its association with outcome of fibrinolytic therapy.

Methods: This was prospective, observational study conducted from June, 2016 to April, 2018. Total 133 patients with prosthetic heart valve thrombosis were included. Routine blood investigations included complete hemogram, liver and renal function tests. Prothrombin time with INR was done on admission. The diagnosis of PHVT was assessed by cine-fluoroscopy (CF) and/or echocardiography (transthoracic/transesophageal). Follow-up at 6 months was scheduled for all patients.

Results: All patients received fibrinolytic therapy in which 108 (81.2%) were treated with streptokinase and 25 (18.8%) were treated with urokinase. On presentation, 48.9% patients were in NYHA class III, 41.4% in NYHA class IV and 9.77% in NYHA class II. Fibrinolytic therapy was successful in 105 patients (78.9%) and it failed in 28 patients (21.1%). Mortality in NYHA class II was 0%, NYHA class III was 4.6% and in NYHA class IV was 23.6%. During 6 months follow up prosthetic heart valve thrombosis recurred in 12 (11.43%) patients.

Conclusion: From our single center experience, fibrinolytic therapy is effective first line therapy for prosthetic heart valve thrombosis and NYHA functional class on presentation can predict the outcome of fibrinolytic therapy.

Keywords

NYHA Class

Prosthetic Heart Valve

Thrombosis

Fibrinolytic Therapy

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Author(s):

Sanjeev Bhatia:[PubMed][Scholar]
Sharad Jain:[PubMed][Scholar]
Vishal Sharma:[PubMed][Scholar]
Zeeshan Mansuri :[PubMed][Scholar]
Krutika Patel:[PubMed][Scholar]
Pragya Jain:[PubMed][Scholar]
Mithilesh Kulkarni:[PubMed][Scholar]
Tanmay Agrawal:[PubMed][Scholar]
Kamal Sharma:[PubMed][Scholar]