Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure

2Department of Genetics, and Infertility & Reproductive Health Research Center(IRHRC), Taleghani Hospital, Shahid Beheshti University of Medical Sciences, fpoures@yahoo.com, I.R.Iran

3Research center for gastroenterology and liver diseases, Taleghani Hospital, Shahid Beheshti University of MedicalmSciences, IR.Iran

International Journal of Endocrinology and Metabolism:Vol. 7, issue 2; 67-71

Article type:Research Article

Received:Jan 01, 2008

Accepted:May 20, 2009

How to Cite:M FallahianF PouresmaeiliF AziziM R ZaliE M SamaniP Kharazihaet al.Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure.Int J Endocrinol Metab.7(2):67-71.

Abstract

Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhea, before the age of 40, for which the Inhibin α-subunit (INHα) gene is proposed as a candidate gene, due to its role in negative feedback control of FSH. In this study we aimed at demonstrating the candidate mutation as a gene variation associated with POF in Iranian population. Materials & Methods: Using DNA sequencing, DNA samples of 24 women with POF and 24 controls, aged below 40 years, were screened for mutations in the Inhibin gene. Results: The 769G→A mutation in exon 2 of the Inhibin-α gene was found in four out of 24 idi-opathic POF patients. Conclusion: The results obtained in this study have shown that this variation is more frequent in patients with POF than in normal fertile pop-ulations of Iran.

Keywords

Inhibin ?-subunit gene

Premature ovarian failure

Mutation

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