Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran

M Taghavi; N Saghafi; S Shirin

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran

Author(s):

M a Taghavi^1,*,

N b Saghafi²,

S b Shirin²

1Departments of Endocrinology,Mashhad University of Medical Sciences, [email protected], IR.Iran

2Gynecology and Obstetrics, Mashhad University of Medical Sciences, I, R.Iran

International Journal of Endocrinology and Metabolism:Vol. 7, issue 2; 82-85

Published online:Apr 30, 2009

Article type:Research Article

Received:Apr 22, 2009

Accepted:May 06, 2009

How to Cite:Taghavi M, Saghafi N, Shirin S. Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran. Int J Endocrinol Metab. 2009;7(2):. doi:

Abstract

Thyroid disorders are common in women during pregnancy, when the excess or deficiency of maternal thyroid hormones has been associated with adverse health outcomes for both the mother and child. This study performed to study the prevalence of thyroid disorders and its effect on pregnancy outcomes in pregnant women. Materials & Methods: In 500 pregnant women in first trimester of pregnancy enrolled for the study, Serum Thyrotropin (TSH), Free T4 (FT4), and Free T3 (FT3) were measured by high-sensitive radioimmunoassay. Overt hyperthy-roidism was diagnosed when both TSH was suppressed and FT4 or FT3 were elevated. Sub-clinical hyperthyroidism was diagnosed when TSH was suppressed with normal FT4 and FT3. The diagnostic criteria for overt hypothyroidism was TSH > 4 mU/L accompanied by decreased FT4, and for subclinical hypothyroidism a TSH > 4 mU/L with normal FT4 level. Those with thyro-id disorders were referred to an endocrinologist for medical treatment and all subjects were fol-lowed until delivery. Results: Mean age of women was 24.5±4.9 years. Hypothyroidism, both subclinical (7.4%) and overt (2.4%), was found in 49 (9.8%) women. Overt hyperthyroidism found in 3 (0.6%) and subclinical hyperthyroidism in 21 (4.2%) women and was considered a physiologic change of pregnancy. On follow up, 19 women (3.8%) had preterm labor, and 25 (5%) women developed pre-eclampsia. There was no significant differ-ence in the incidence of preterm labor and pre-eclampsia in pregnant women with or without thyroid dysfunction. Normal neonates were born to 498 women, while 2 (0.4%) euthyroid mothers delivered fetuses with anomalies. Conclusion: Although thyroid dysfunction is common in pregnant women, the prevalence of complications is not higher in patients with thy-roid dysfunction, as compared to normal euthy-roid controls.

Keywords

Hyperthyroidism

Hypothyroidism

Pregnancy

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Author(s):

M Taghavi:[PubMed][Scholar]
N Saghafi:[PubMed][Scholar]
S Shirin:[PubMed][Scholar]

Research Institute for Endocrine Sciences

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Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran

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