The G360t Polymorphism in the APO AIV Gene and its Association with Combined HDL/LDLCholesterol Phenotype: Tehran Lipid and Glucose Study

MS Daneshpour; M Zarkesh; M Hedayati; SM Mesbah; S Halalkhor; B Faam; F Azizi

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

Current Issue All Issues In Press Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

The G360t Polymorphism in the APO AIV Gene and its Association with Combined HDL/LDLCholesterol Phenotype: Tehran Lipid and Glucose Study

Author(s):

MS Daneshpour¹,

M Zarkesh¹,

M Hedayati¹,

SM Namin Mesbah¹,

S Halalkhor¹,

B Faam¹,

F Azizi

^2,*

1Obesity Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, IR.Iran

2Endocrine Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, azizi@endocrine.ac.ir, IR.Iran

International Journal of Endocrinology and Metabolism:Vol. 8, issue 1; 32-38

Article type:Research Article

How to Cite:MS DaneshpourM ZarkeshM HedayatiSM Namin MesbahS HalalkhorB FaamF Aziziet al.The G360t Polymorphism in the APO AIV Gene and its Association with Combined HDL/LDLCholesterol Phenotype: Tehran Lipid and Glucose Study.Int J Endocrinol Metab.8(1):32-38.

Abstract

Identifying genetic polymorphisms as risk factors for complex diseases can facilitate their prevention, diagnosis, and prognosis. The purpose of this study is to assess the association between Apo AIV polymorphism and lipid factors based on high density lipoprotein cholesterol (HDL-C) levels in a population of the Tehran Lipid and Glucose Study (TLGS). Materials and Methods: A total of 181 elderly TLGS subjects with Combined HDLC/low density lipoprotein-Cholesterol (LDL-C) phenotype were investigated. The distributions of a polymorphic site in the apolipoprotein gene APO AIV and its relationship with total cholesterol, LDL-C, HDL-C, and triglycerides were investigated in subjects with LDL-C> 121 mg/dL and HDL-C< 40 mg/dL (case group) and those with LDL-C< 90 mg/dL and HDL-C> 50 (controls). Results: All the variables studied in the case and control groups were statistically different. At the APO AIV locus the G360T polymorphism at codon 360 showed a significant impact on total cholesterol (G: 211±1.16 vs, T: 228±1.20 mg/dL p 0.038) concentration in the case group and on Apo CIII (G: 157±66.9 vs, T: 83.18±17.1 mg/dL p <0001) level in the controls. These associations remained after adjustment for age, sex and smoking (P values: P Chol: 0.028 and P Apo CIII: 0.021). Conclusion: Difference in the apolipoprotein AIV (G360T) polymorphism in the two groups with the combined HDL/LDL-C phenotype indicates that this phenotype can be a selective phenotype for genetic analysis in this field.

Keywords

Apolipoprotein AIV

polymorphism

cholesterol

Full Text

Full text is available in PDF

comments