Does Supplementation with Calcium During Pregnancy Affect the Mineral Concentration in Mature Breast-Milk?


avatar M Karandish 1 , * , avatar A Djazayery 2 , avatar KF Michaelsen 3 , avatar A Rashidi 2 , avatar B Mohammadpour-Ahranjani 2 , avatar A Behrooz 4 , avatar Cc Mlgaard 3

Department of Nutrition, Paramedical School, Ahwaz Jondi-Shapour University of Medical Sciences, [email protected], Iran
Department of Nutrition and Biochemistry, School of Public Health,Tehran University of Medical Sciences, Iran
Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark
Department of Gynecology, School of Medicine, Ahwaz Jondi-Shapour University of Medicine Sciences, Iran

how to cite: Karandish M, Djazayery A, Michaelsen K, Rashidi A, Mohammadpour-Ahranjani B, et al. Does Supplementation with Calcium During Pregnancy Affect the Mineral Concentration in Mature Breast-Milk?. Int J Endocrinol Metab.5(4): 134-141.


Although the relationship between calcium in-take during lactation and breast milk calcium concentration has been studied by many inves-tigators, evidence available on the effects of calcium supplementation during pregnancy on the calcium content of breast-milk is limited. The aim of this double-blind placebo-controlled trial was to determine the effect of calcium supplementation during the 3rd tri-mester of pregnancy on the calcium concentra-tion of mature breast-milk. Materials and Methods: Sixty-eight pregnant women in Ahwaz city, southwest Iran were randomly assigned to the “Calcium” (1 gr/d) or “Placebo” groups from the 28th-30th week of gestation until delivery. Breast-milk samples were taken 1.5 to 3 months after delivery. Cal-cium concentrations were measured using atomic absorption spectrometry. There were no significant differences between the two groups with respect to the demographic characteristics, anthropometric indices, and dietary energy and calcium intakes, at baseline. Results: No differences were found in calcium concentrations in mature breast-milk between the two groups [mean±SD were 228±38 and 235±42 mg/L in the calcium and placebo groups, respectively, (P=0.49)]. Conclusion: Our study did not support the hy-pothesis that calcium supplementation during pregnancy affects the calcium concentration later in mature breast-milk.

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