Clinical and Laboratory Features of Patients with Impaired Glucose Tolerance (IGT) in Adults of District 13 of Eastern Tehran

authors:

avatar M Iranparvar Alamdari 1 , * , avatar AS Habibi Moini 2 , avatar A Ebady 3 , avatar F Azizi 2

Ardebil University of Medical Sciences, Ardebil, Alamdar95@Yahoo.com, Kashan, I.R.Iran
Endocrine and Metabolism Research Center, Shaheed Beheshti University of Medical Sciences, Kashan, I.R.Iran
International Journal of Endocrinology and Metabolism: Vol.6, issue 3; 116-122
article type: Original Article
received: May 25, 2007
accepted: July 27, 2007

How To Cite Iranparvar Alamdari M, Habibi Moini A, Ebady A, Azizi F. Clinical and Laboratory Features of Patients with Impaired Glucose Tolerance (IGT) in Adults of District 13 of Eastern Tehran. Int J Endocrinol Metab. 2008;6(3): 116-122. 

Abstract

Patients with IGT have increased risk of developing DM type II and non-communicable diseases in the future. The aim of this study was to determine the features of patients with IGT in Tehran and the cor-relation of IGT with other variables and risk factors of non communicable diseases. Materials and Methods: This study was a descriptive analytical and cross–sectional one, in which 960 of 9204 persons, participants of the first phase of Te-hran Lipid and Glucose Study (TLGS) were found to have IGT in the initial assessment; eight weeks later, a second OGTT was done, and 331 had IGT. DM and IGT diagnosis were based on WHO crite-ria; in this group, anthropometric indices, BP, serum glucose, and lipid level were assessed after 12 hours of fasting. Obesity was defined as BMI≥30 kg/m2 and over weight as BMI between 25 and 29.9 kg/m2. WHR over 0.8 in females and 0.95 in males were de-fined as truncal obesity. Hypertension was defined as SBP≥140 or DBP≥90 mmHg or taking anti hyper-tensive drugs. Statistical analyses were performed using independent T-test, and ANOVA. Results: Totally 331 patients with IGT were studied, of whom 232 (70%) were female and 99 (30%) were male. In 43% of cases, BMI was ≥30. WHR was ab-normal in 83.7%; total cholesterol level in 32% was ≥240 mg/dL, LDL in 28.1% was ≥130 mg/dL and ≥ 160 g/dL in 24.8%; HDL in 32.9% of cases was <35 mg/dL. In 43.2% of cases, TG was ≥200 mg/dL. As-sessment of parameters according to BMI showed that mean cholesterol and triglyceride levels in obese patients were higher than the rest (p<0.05, p<0.001) and mean HDL cholesterol in obese pa-tients was lower (p<0.014). Exercise tolerance test (ETT) was performed in 199 patients, and was posi-tive in 14% . Conclusion: According to the results of this study, patients with IGT have a high risk of cardiovascular events because of multiple risk factors such as obe-sity, hypertension, smoking, and hyper lipidemia.

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