Clinical and Laboratory Features of Patients with Impaired Glucose Tolerance (IGT) in Adults of District 13 of Eastern Tehran

M Iranparvar Alamdari; AS Habibi Moini; A Ebady; F Azizi

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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Clinical and Laboratory Features of Patients with Impaired Glucose Tolerance (IGT) in Adults of District 13 of Eastern Tehran

Author(s):

M Iranparvar Alamdari^1,*,

AS Habibi Moini²,

A Ebady³,

F Azizi²

1Ardebil University of Medical Sciences, Ardebil, Alamdar95@Yahoo.com, Kashan, I.R.Iran

2Endocrine and Metabolism Research Center, Shaheed Beheshti University of Medical Sciences, Kashan, I.R.Iran

International Journal of Endocrinology and Metabolism:Vol. 6, issue 3; 116-122

Article type:Research Article

Received:May 25, 2007

Accepted:Jul 27, 2007

How to Cite:M Iranparvar AlamdariAS Habibi MoiniA EbadyF AziziClinical and Laboratory Features of Patients with Impaired Glucose Tolerance (IGT) in Adults of District 13 of Eastern Tehran.Int J Endocrinol Metab.6(3):116-122.

Abstract

Patients with IGT have increased risk of developing DM type II and non-communicable diseases in the future. The aim of this study was to determine the features of patients with IGT in Tehran and the cor-relation of IGT with other variables and risk factors of non communicable diseases. Materials and Methods: This study was a descriptive analytical and cross–sectional one, in which 960 of 9204 persons, participants of the first phase of Te-hran Lipid and Glucose Study (TLGS) were found to have IGT in the initial assessment; eight weeks later, a second OGTT was done, and 331 had IGT. DM and IGT diagnosis were based on WHO crite-ria; in this group, anthropometric indices, BP, serum glucose, and lipid level were assessed after 12 hours of fasting. Obesity was defined as BMI≥30 kg/m2 and over weight as BMI between 25 and 29.9 kg/m2. WHR over 0.8 in females and 0.95 in males were de-fined as truncal obesity. Hypertension was defined as SBP≥140 or DBP≥90 mmHg or taking anti hyper-tensive drugs. Statistical analyses were performed using independent T-test, and ANOVA. Results: Totally 331 patients with IGT were studied, of whom 232 (70%) were female and 99 (30%) were male. In 43% of cases, BMI was ≥30. WHR was ab-normal in 83.7%; total cholesterol level in 32% was ≥240 mg/dL, LDL in 28.1% was ≥130 mg/dL and ≥ 160 g/dL in 24.8%; HDL in 32.9% of cases was <35 mg/dL. In 43.2% of cases, TG was ≥200 mg/dL. As-sessment of parameters according to BMI showed that mean cholesterol and triglyceride levels in obese patients were higher than the rest (p<0.05, p<0.001) and mean HDL cholesterol in obese pa-tients was lower (p<0.014). Exercise tolerance test (ETT) was performed in 199 patients, and was posi-tive in 14% . Conclusion: According to the results of this study, patients with IGT have a high risk of cardiovascular events because of multiple risk factors such as obe-sity, hypertension, smoking, and hyper lipidemia.

Keywords

Impaired glucose tolerance

cardio-vascular disease risk factors

obesity

hyperten-sion

lipid disorders

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