Subclinical Hypothyroidism

Subclinical hypothyroidism (SCH) is defined as a normal serum FT4 and a high serum thyrotro-pin (TSH) concentration. Up to 30% of patients with SCH may have vague, non-specific symp-toms of hypothyroidism, but attempts to identify the patients on the basis of clinical finding have not been successful, so the diagnosis can only be made with laboratory testing. The causes of SCH are the same as those of overt hypothyroidism. Most patients have Hashimoto’s thyroiditis. The worldwide preva-lence of SCH ranges from 1-10%. A substantial proportion of patients with SCH develop overt hypothyroidism. Serum TSH concentration and positive antithyroid antibodies (ATA) are sig-nificant predictors of progression to clinical hy-pothyroidism. Some patients with SCH have some symptoms of hypothyroidism, while some studies show significant improvement in hypo-thyroid symptom scores and psychometric test-ing; others found no improvement in symptoms with levothyroxine therapy. There is consensus that SCH in pregnancy is a risk factor for poor developmental outcomes in the offspring and the condition should be treated in women who wish to become pregnant. There is also agreement that patients with SCH and TSH levels over 10 mU/L, or with goiter should be treated. Population-based screening for SCH is not warranted, but thyroid function should be tested in high risk groups, e.g. in women aged over 60 yr, persons with previous radiation therapy of thyroid gland or external radiation, those with previous thyroid surgery of thyroid dysfunction, type 1 diabetes mellitus pa-tients and those with a family history of auto-immune disease. Evidence documenting routine determination of TSH in pregnant women or women planning to become pregnant are insuf-ficient, and it would be reasonable to consider TSH measurement in those at high risk for thy-roid dysfunction.

Keywords

Subclinical

Hypothyroidism

Thyrotropin

Thyroiditis

Antithyroid antibodies

Full Text

Full text is available in PDF

Management of Subclinical Hyperthyroidism

Silvia Santos Palacios,

Eider Pascual-Corrales,

Juan Carlos Galofre

Santos Palacios S, Pascual-Corrales E, Galofre JC. Management of Subclinical Hyperthyroidism. Int J Endocrinol Metab. 2012;10(2):. doi: https://doi.org/10.5812/ijem.3447

31

Jan

2005

The Frequency of Thyroid Autoantibodies is Higher in the Upper Range of Normal Thyrotropin Values

Peimaneh Heydarian,

F Azizi

Heydarian P, Azizi F. The Frequency of Thyroid Autoantibodies is Higher in the Upper Range of Normal Thyrotropin Values. Int J Endocrinol Metab. 2005;3(1):e102730. doi:

30

Apr

2009

Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran

M a Taghavi,

N b Saghafi,

S b Shirin

Taghavi M, Saghafi N, Shirin S. Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran. Int J Endocrinol Metab. 2009;7(2):. doi:

24

Jul

2021

A Clinical Debate: Subclinical Hypothyroidism

Sina Jasim,

Hengameh Abdi,

Hossein Gharib,

Bernadette Biondi

Jasim S, Abdi H, Gharib H, Biondi B. A Clinical Debate: Subclinical Hypothyroidism. Int J Endocrinol Metab. 2021;19(3):e115948. doi: https://doi.org/10.5812/ijem.115948

1

Sep

2023

Diagnosis and Management of Congenital Hypothyroidism: An Updated Overview

Shahin Koohmanaee,

Arash Bakhshi,

Shayan Pourkazem,

Behrang Motamed

Koohmanaee S, Bakhshi A, Pourkazem S, Motamed B. Diagnosis and Management of Congenital Hypothyroidism: An Updated Overview. J Compr Ped. 2023;14(4):e138532. doi: https://doi.org/10.5812/jcp-138532

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 week ago
Scopus by Title: 0
Last Update: 1 week ago
Scopus by Title (Ref): 3
Last Update: 1 week ago
CrossRef: 0
Last Update: 2 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

S Kalantari:[PubMed][Scholar]

Research Institute for Endocrine Sciences

Outlines

Subclinical Hypothyroidism

Abstract

Full Text

Similar Articles

Management of Subclinical Hyperthyroidism

The Frequency of Thyroid Autoantibodies is Higher in the Upper Range of Normal Thyrotropin Values

Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran

A Clinical Debate: Subclinical Hypothyroidism

Diagnosis and Management of Congenital Hypothyroidism: An Updated Overview

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 2 days ago