Methimazole-Induced Agranulocytosis in a Mother and her Young Daughter, the Possible Role of Genetic Factors in the Development of Methimazole- Induced Agranulocytosis

authors:

avatar A Bahrami 1 , *

Division of Endocrinology and Metabolism, Department of Medicine, Tabriz University of Medical Sciences, t.u.end.d@tbzmed.ac.ir, IR.Iran

how to cite: Bahrami A. Methimazole-Induced Agranulocytosis in a Mother and her Young Daughter, the Possible Role of Genetic Factors in the Development of Methimazole- Induced Agranulocytosis. Int J Endocrinol Metab. 2006;4(2): 112-115. 

Abstract

Agranulocytosis is a rare but life-threatening side effect of thionamides. Some data indicate that the susceptibility to thionamide-associated agranulocytosis in patients with Graves? disease has a genetic basis. The case histories of a mother and her daughter with Graves? disease who developed agranulocytosis with methima-zole are presented here. It seems reasonable to avoid the use of thionamide derivates in hyper-thyroid relatives of patients who have had thionamide-induced agranulocytosis.

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