Spontaneous ovarian hyperstimulation in pregnant women with hypothyroidism

Spontaneous hyperstimulations syndrome had been reported in women with hypothyroidism, and polycysticovary syndrome. This report describesa case in which a naturally conceived pregnancy was associated with spontaneous ovarian hyper stimulation and hypothyroidism.1-4We treated our case by levothyroxine. Within 2 weeks a remarkable improvement was observed, with resolution of ascites and decrease in serum TSH level. The hormonal tests for thyroid function were normal 3 months after treatment. Pregnancy was allowed to proceed under close maternal and fetal surveillance. The mother’s progress was then followed at normal antenatal check-ups and no serious complications developed. Ten weeks after delivery ovarian cysts regressed completely. Thyroid hormone replacement seems to be the best therapeutic approach, but in some patients the complete resolution of the ovarian cysts does not take place after being euthyroid.has been extensively described after treatment with exogenous gonadotropins, clomiphene citrate, and gonadotropin releasing hormone. OHSS, not related to ovulation induction is rare. Spontaneous hyperstimulation syndrome has been reported in women with hypothyroidism, polycystic ovary syndrome and pregnancy), gonadotroph pituitary adenoma, and normal pregnancy.1-4This report describes a case in which a naturally conceived pregnancy is associated with spontaneous ovarian hyper stimulation and hypothyroidism.