Tako-Tsubo Cardiomyopathy and Thyroid Dysfunction

How to Cite:Sarullo F, Di Franco A, Di Monaco A, Magro S, Nerla R, et al. Tako-Tsubo Cardiomyopathy and Thyroid Dysfunction. Int J Endocrinol Metab. 2011;9(4):. doi: https://doi.org/10.5812/Kowsar.1726913X.3386

Abstract

First described in a Japanese population in 1991, the Tako-Tsubo disease has recently been included among the primary acquired cardiomyopathies in the American Heart Association’s disease classifications. Tako-Tsubo cardiomyopathy (TTC) is a reversible, often misdiagnosed condition, as it can easily mimic acute coronary syndrome. It has indeed been estimated that TTC can represent 1 to 2% of patients who present with suspected acute coronary syndrome. The disease is especially common in women. In its typical presentation, the identifying characteristic of TTC is the systolic bulging of the heart’s apex with preserved contraction of basal myocardial segments. The acute left ventricular dysfunction, however, it is usually reversible, with contractile function usually recovering in a few weeks. The etiology of TTC is not completely clear. Many theories have been proposed, taking into account the role of hormone disturbances, acute toxic effects of catecholamines on cardiomyocytes, diffuse microvascular spasms, multivessel epicardial spasms, and acute myocarditis. Several researchers have suggested that TTC may occur as a rare complication of dysthyroidism. In particular, an acute hyperthyroid state has been proposed to be capable of triggering TTC, independently of its causes. Indeed, several cases of TTC associated with Graves’ disease, Hashimoto thyroiditis, or excess levothyroxine therapy have been reported in the medical literature. The mechanism by which dysthyroidism can trigger TTC, however, remains poorly understood. In this review we investigated the role of thyroid dysfunction as a possible trigger for TTC.

Keywords

Tako-Tsubo Cardiomyopathy

Thyroid Dysfunction

Ventricular Function

Fulltext

Full text is available in PDF

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 3
Last Update: 1 day ago
Scopus by Title: 3
Last Update: 1 day ago
Scopus by Title (Ref): 3
Last Update: 1 day ago
CrossRef: 4
Last Update: 1 day ago

Metrics

Get Permission (article level)

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Filippo Sarullo:[PubMed][Scholar]
Antonino Di Franco:[PubMed][Scholar]
Antonio Di Monaco:[PubMed][Scholar]
Serena Magro:[PubMed][Scholar]
Roberto Nerla:[PubMed][Scholar]
Ylenia Salerno:[PubMed][Scholar]
Giorgio Mandala:[PubMed][Scholar]
Gaetano A. Lanza:[PubMed][Scholar]

Research Institute for Endocrine Sciences

Outlines

Tako-Tsubo Cardiomyopathy and Thyroid Dysfunction

Abstract

Fulltext

Crossmark

Checking

Last Update: 1 day ago

Last Update: 1 day ago

Last Update: 1 day ago

Last Update: 1 day ago