Cardiovascular Risk in Women With PCOS


avatar Pietro Scicchitano 1 , avatar Ilaria Dentamaro 1 , avatar Rosa Carbonara 1 , avatar Gabriella Bulzis 1 , avatar Annamaria Dachille 1 , avatar Paola Caputo 1 , avatar Roberta Riccardi 1 , avatar Manuela Locorotondo 1 , avatar Cosimo Mandurino 1 , avatar Marco Matteo Matteo Ciccone 1 , *

Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico,, Italy

how to cite: Scicchitano P, Dentamaro I, Carbonara R, Bulzis G, Dachille A, et al. Cardiovascular Risk in Women With PCOS. Int J Endocrinol Metab. 2012;10(4): 611-618.


Polycystic ovary syndrome (PCOS), or Stein-Leventhal syndrome, is a common endocrine disorder defined by two of the three following features: i) oligoovulation or anovulation, ii) clinical and/or biochemical signs of hyperandrogenism, or iii) polycystic ovaries, once the related endocrinological and gynaecological disorders have been excluded. PCOS does not exclusively involve the reproductive apparatus , it has a complex number of systemic relevancy symptoms. It leads to Metabolic Syndrome, with severe consequences on the cardiovascular apparatus. Many clinical studies have underlined the connection between PCOS and the cardiovascular risk profile of such female patients, due to a lipid/glucose altered metabolism, hypertension, systemic inflammatory condition (assessable by markers such as VES, TNF-alfa, citokines and C-reactive protein (hsPCR) levels), and vascular injuries. Considering the early onset of the disease, PCOS could be considered as a real cardiovascular risk factor which affects the quality of life seriously. The current review aimed to point out the main connections between PCOS and cardiovascular risk factors according to the latest findings coming from literature data analysis, and try to depict the great influences that such a common disease can have on the patients health integrity.

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© 2012, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.