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Postprandial Peaking and Plateauing of Triglycerides and VLDL in Patients with Underlying Cardiovascular Diseases Despite Treatment

Author(s):
Clarissa E. E. SamsonClarissa E. E. Samson1, Ana Lyza B. B. GaliaAna Lyza B. B. Galia1, Khristine Ivy C. C. LlaveKhristine Ivy C. C. Llave2, Manuel B. B. ZacariasManuel B. B. Zacarias3, Leilani B. B. Mercado-AsisLeilani B. B. Mercado-Asis1,*
1Section of Endocrinology and Metabolism, University Of Santo Tomas Hospital, leilanimercadoasis@endo-society.org.ph, Philippines
2Dietary Services, University of Santo Tomas Hospital, Philippines
3Section of Cardiology, University of Santo Tomas Hospital, Philippines


International Journal of Endocrinology and Metabolism:Vol. 10, issue 4; 587-593
Published online:Sep 29, 2012
Article type:Research Article
Received:Mar 08, 2012
Accepted:May 23, 2012
How to Cite:Clarissa E. E. SamsonAna Lyza B. B. GaliaKhristine Ivy C. C. LlaveManuel B. B. ZacariasLeilani B. B. Mercado-AsisPostprandial Peaking and Plateauing of Triglycerides and VLDL in Patients with Underlying Cardiovascular Diseases Despite Treatment.Int J Endocrinol Metab.10(4):587-593.https://doi.org/10.5812/ijem.4783.

Abstract

Background:

Dyslipidemia is associated with cardiovascular morbidities and mortality. Currently, fasting lipid profile determination is used to monitor treatment response. Recently, postprandial lipemia is of increasing interest because of its atherogenic and thrombogenic potential and also was found to be more predictive for cardiovascular diseases.

Objectives:

To demonstrate postprandial lipemia among patients with cardiovascular diseases despite low fat diet, normal fasting lipid profile and even statin regimen.

Patients and Methods:

Patients aged 40-80 years old with cardiovascular diseases (i.e. coronary artery disease and cerebrovascular disease) more than 6 months, on statin treatment for more than 6 months and normal fasting lipid profile (according to NCEP ATP III guidelines) were included. Study exclusion criteria were pregnancy, acute cardiovascular events < 6 months, hepatic or renal failure. Finally, twelve patients were included.

Results:

The triglyceride level showed a significant rise from fasting to 2 hours after breakfast with a mean difference of 23.86 mg/dL (P =0.012). The level peaked at 4 hours after breakfast with a mean difference (MD) of 72.02 mg/dL (P =0.002). Subsequent triglyceride levels plateaued and were significantly higher than the baseline (P

Conclusions:

Triglyceride and VLDL peaking and plateauing were observed in patients with cardiovascular diseases despite low fat diet, normal fasting lipid profile and statin regimen. These findings may raise more attentions in monitoring and management of dyslipidemia in patients with cardiovascular and cerebrovascular events.

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