GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome


avatar Pilar Alama 1 , avatar Jose Bellver 2 , avatar Carmen Vidal 1 , avatar Juan Giles 1 , *

Department of Reproduction, IVI-Valencia, Plaza de la Policia Local, Valencia, Spain
Department of Paediatrics, Obstetrics and Gynaecology, Faculty of Medicine. University of Valencia, Valencia, Spain

how to cite: Alama P, Bellver J, Vidal C, Giles J. GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome. Int J Endocrinol Metab. 2013;11(2): 107-16.



The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article.

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