article information

International Journal of Endocrinology and Metabolism: Vol.11, issue 1; 23-26
published online: December 21, 2012
article type: Original Article
received: October 2, 2012
accepted: November 24, 2012
DOI: 10.5812/ijem.8403
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Number of Components of the Metabolic Syndrome; Smoking and Inflammatory Markers

authors:

avatar Tomoyuki Kawada 1 , * , avatar Toshiaki Otsuka 1 , avatar Tokiomi Endo 2 , avatar Yoichi Kon 2

Department of Hygiene and Public Health, Nippon Medical School, Bunkyo-Ku, [email protected], Japan
Division of Health Evaluation & Promotion, Ota Memorial Hospital, Ota-city, Japan

how to cite: Kawada T, Otsuka T, Endo T, Kon Y. Number of Components of the Metabolic Syndrome; Smoking and Inflammatory Markers. Int J Endocrinol Metab.11(1): 23-26. doi: 10.5812/ijem.8403.

Abstract

Background:

The association between inflammatory markers and the combination of the smoking status plus a number of components of the metabolic syndrome was not fully evaluated in male Japanese subjects.

Objectives:

To demonstrate the association between inflammatory markers and the number of components of the metabolic syndrome by considering smoking status.

Patients and Methods:

A total of 3,017 male subjects (1,047 current smokers, 1,970 non-smokers) were included. Metabolic syndrome (MetS) was defined by the criteria of the National Cholesterol Education Program Adult Treatment Panel III. The smoking status was categorized in a binary manner into current smokers or non-smokers.

Results:

The geometric mean value of the serum CRP increased linearly as the number of components of MetS increased (P < 0.05). In contrast, the mean values of the total WBC, neutrophil, lymphocyte and monocyte counts showed peak values when the number of MetS components was 3 or 4. The log-transformed serum CRP levels and the WBC counts were significantly correlated with one another (P < 0.001), but Pearsons correlation coefficient was under 0.3 for current smokers.

Conclusions:

Among several inflammatory markers, the serum CRP predominantly changed linearly as the number of MetS increased regardless of smoking status.

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