Background:The association between inflammatory markers and the combination of the smoking status plus a number of components of the metabolic syndrome was not fully evaluated in male Japanese subjects.
Objectives:To demonstrate the association between inflammatory markers and the number of components of the metabolic syndrome by considering smoking status.
Patients and Methods:A total of 3,017 male subjects (1,047 current smokers, 1,970 non-smokers) were included. Metabolic syndrome (MetS) was defined by the criteria of the National Cholesterol Education Program Adult Treatment Panel III. The smoking status was categorized in a binary manner into current smokers or non-smokers.
Results:The geometric mean value of the serum CRP increased linearly as the number of components of MetS increased (P < 0.05). In contrast, the mean values of the total WBC, neutrophil, lymphocyte and monocyte counts showed peak values when the number of MetS components was 3 or 4. The log-transformed serum CRP levels and the WBC counts were significantly correlated with one another (P < 0.001), but Pearsons correlation coefficient was under 0.3 for current smokers.
Conclusions:Among several inflammatory markers, the serum CRP predominantly changed linearly as the number of MetS increased regardless of smoking status.
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