Effects of Purified Omega-3 Fatty Acids on Serum Lipoproteins and Malondialdehyde in Postmenopausal Fat Women Receiving Hormone Replacement Therapy

authors:

avatar Shidfar F 1 , * , avatar Keshavarz A 2 , avatar Jalali M 1 , avatar Miri R 3 , avatar Amri A 1 , avatar Shidfar SH 4

School of Health, Iran University of Medical Sciences, farzadshidfar@yahoo.com, IR Iran
School of Public Health, Tehran University of Medical Sciences, IR Iran
Shaheed Beheshti University of Medical Sciences
dMemorial Hospital, University of Massachusetts, USA
International Journal of Endocrinology and Metabolism: Vol.2, issue 2; 87-94
published online: September 1, 2004
article type: Original Article

how to cite: F S, A K, M J, R M, A A, et al. Effects of Purified Omega-3 Fatty Acids on Serum Lipoproteins and Malondialdehyde in Postmenopausal Fat Women Receiving Hormone Replacement Therapy. Int J Endocrinol Metab. 2004;2(2): 87-94. 

Abstract

Introduction:

Regular intake of n-3 fatty acids of marine origin have desirable effects on serum lipoproteins and reduce coronary vascular disease (CVD). n-3 fatty acid supplementation decreased serum triglyceride concentrations in studies in which most of the subjects were male. The effects of n-3 fatty acids supplementation in fat women especially postmenopausal fat women have received little attention. The aim of this study was to determine whether purified n-3 fatty acids have desirable effects on serum lipoproteins, malondialdehyde (MDA) and lipoprotein risk factors for CVD in postmenopausal fat women receiving hormone replacement therapy (HRT).

Materials and Methods:

In a double-blind, placebo-controlled trial of parallel design, 35 postmenopausal women receiving hormone replacement therapy were randomly allocated to receive 2 g purified n-3 fatty acids or placebo for 10 weeks. Serum lipoproteins and MDA were determined on days 0 and 70.

Results:

Serum levels of triglycerides (TG) decreased significantly in the n-3 fatty acids group at the end of study compared to the initial values, and also compared to control group (26%, p< 0.003 and 29%, p< 0.01, respectively)_In the n-3 fatty acids group, serum levels of TG/HDL-C decreased significantly at the end of the study compared to initial values and, at the end of the study, compared to control group as well (23 %, P <0.05 and 28%, p< 0.05).

Conclusion:

Supplementation with purified n-3 fatty acids can favorably influence selected CHD risk factors, particulary by achieving marked reduction in serum TG and TG/HDL-C levels in postmenopausal fat women receiving HRT.

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