Hyperthyroidism Associated Congestive Heart Failure: A Case-Control Study


avatar G Papi 1 , * , avatar G Chesi 2 , avatar S A Corsello 2 , avatar C DiDonato 2 , avatar M T Milite 2 , avatar AV Vittoria Ciardullo 2 , avatar A Ponte-corvia 2 , avatar E Roti 3

Department of Internal Medicine, Azienda USL Modena, papigiampaolo@hotmail.com, Italy
Department of Internal Medicine, Azienda USL Reggio Emilia, Italy
Internal Medicine Unit, Suzzara Hospital SpA HSS, Italy

how to cite: Papi G, Chesi G, Corsello S, DiDonato C, Milite M, et al. Hyperthyroidism Associated Congestive Heart Failure: A Case-Control Study. Int J Endocrinol Metab. 2009;7(2): 86-94. 


Hyperthyroidism has been associated with cardiomyopathy and heart failure (HF). This study aims to evaluate clinical, laboratory and echocardiographic parameters, at admission and 12 months following euthyroidism restoration, in patients with hyperthyroidism-associated HF. Mechanisms underlying hyperthyroidism-associated HF and the outcomes of echocardiographic parameters along the study period are both discussed. Materials & Methods: Patients with newly di-agnosed overt hyperthyroidism and HF (Group 1), age and sex-matched euthyroid HF subjects (Group 2), and a control group were enrolled. Results: In the 38-month study period, 56 patients were admitted for hyperthyroidism-associated HF, of whom 71% had a pre-existing, mainly hypertensive, cardiomyopathy vs 68% of Group 2 subjects. Mean heart rate was significantly higher in Group 1 than Group 2 (127±38 vs 110±17bpm; P <0.02); 30 Group 1 (54%) and 16 (29%) Group 2 patients presented with atrial fi-brillation. At admission, left ventricular ejection fraction (LVEF), end diastolic (LVEDD) and end systolic (LVESD) diameters were lower, whilst LV mass (LVM), interventricular septum thick-ness (IVST) and LV posterior wall thickness (LVPWT) were increased in both Groups com-pared to controls. At the end of the study, despite achievement of euthyroidism in all hyperthyroid patients, mean LVEF was not significantly different in Group 2 but was significantly lower in Group 1 patients compared to controls; LVM, IVST and LVPWT did not change in both study groups. Conclusion: In our series, newly diagnosed hyperthyroidism-associated HF had 2.4% preva-lence. At the end of the study, LVEF significantly improved in euthyroid, but not in hyperthy-roidism-associated HF patients compared to con-trols.

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