Sodium Potassium ATPase and Glucose 6 Phosphate Dehydrogenase Activity in Patients with Hyperthyroidism: A Comparison with Euthyroid Patients

A Prasad; S Nayak

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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Sodium Potassium ATPase and Glucose 6 Phosphate Dehydrogenase Activity in Patients with Hyperthyroidism: A Comparison with Euthyroid Patients

Author(s):

A Prasad^1,*,

S Nayak²

1Department of Biochemistry, Kasturba Medical College, Madhavanagar, 576104, anushreprasad@gmail.com, India

2Department of Biochemistry, Kasturba Medical College, Madhavanagar, 576104, India

International Journal of Endocrinology and Metabolism:Vol. 7, issue 1; 5-11

Article type:Research Article

Received:Dec 25, 2008

Accepted:Jan 29, 2009

How to Cite:A PrasadS NayakSodium Potassium ATPase and Glucose 6 Phosphate Dehydrogenase Activity in Patients with Hyperthyroidism: A Comparison with Euthyroid Patients.Int J Endocrinol Metab.7(1):5-11.

Abstract

Background: Sodium potassium ATPase (Na+-K+ ATPase) and Glucose 6 phosphate dehydrogenase (G 6 PD) activities in different tissues have been found to be stimulated by thyroid hormones. In erythrocytes, the activities of these enzymes were reported to vary. The aim of our study was to determine the sodium potassium AT-Pase and glucose 6 phosphate dehydrogenase ac-tivities in patients with hyperthyroidism and compare them with those of patients with euthy-roid goiter.

Materials and Methods: After approval from the Institutional Ethics Committee and obtaining in-formed consent from all patients, 40 hyperthyro-id patients (17 men, 23 women; mean age 44.75±2.6 years) and 50 patients with euthyroid goiter (13 men, 37 women; mean age 37.2±1.6 years) were included in the study. They were classified based on T3, T4, TSH measurements. Erythrocyte Na+-K+ ATPase and G 6 PD activity were measured using spectrophotometry.

Results: In hyperthyroid patients, Na+-K+ AT-Pase activity was significantly lower compared to euthyroid controls (134.98±3.78 vs. 164.34±3.85 nmol pi/hr.mg protein, p<0.001) and G 6 PD le-vels were significantly elevated when compared to euthyroid controls (19.19±0.438 U/g Hb vs. 11.505±0.385 U/g Hb, p<0.001).

Conclusion: Hyperthyroidism is associated with decrease in Na+-K+ ATPase activity and increase in G 6 PD levels when compared to patients with euthyroid goiter. The measurement of Na+-K+ ATPase activity could be used as an early marker for diagnosis of hyperthyroidism.

Keywords

Sodium potassium ATPase

Glucose 6 phosphate dehydrogenase

Hyperthyroidism

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