Trends of Serum Thyrotropin Concentration and Associated Factors in Urban Pakistan (Karachi)

M Riaz; A Salman; A Fawwad; MZ Iqbal Hydrie; M Yakoob Ahmadani; A Basit; AS Shera

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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Trends of Serum Thyrotropin Concentration and Associated Factors in Urban Pakistan (Karachi)

Author(s):

M Riaz^1,*,

A Salman²,

A Fawwad²,

MZ Iqbal Hydrie²,

M Yakoob Ahmadani³,

A Basit²,

AS Shera²

1Department of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, research@bideonline.com, Pakistan

2Department of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Pakistan

3Department of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Pakistan

International Journal of Endocrinology and Metabolism:Vol. 7, issue 1; 12-19

Article type:Research Article

Received:Dec 02, 2008

Accepted:Feb 04, 2009

How to Cite:M RiazA SalmanA FawwadMZ Iqbal HydrieM Yakoob AhmadaniA BasitAS Sheraet al.Trends of Serum Thyrotropin Concentration and Associated Factors in Urban Pakistan (Karachi).Int J Endocrinol Metab.7(1):12-19.

Abstract

Background:This investigation aimed at assessing trends of TSH levels and associated factors in apparently normal subjects of urban Pakistan (Karachi).
Materials and Methods: The survey was conducted in 2004 in Lyari, Karachi. Using a geographical imaging system, 85, 520 households were identified, of which 532 were randomly se-lected; 867 adults aged ≥25 years consented to take part in the study. Blood samples from 324 subjects were available for analyses. Subjects with previous history of thyroid disorders were excluded.
Results: Mean age of subjects was 40.8±14.13 years; 68.2% were females; mean values of waist circumference of males and females were 89.5±16 cm and 87.8±15.7 cm respectively. Fifty-nine (18.2%) subjects had TSH>6.0 (mU/L) based on the ELISA laboratory reference range, used for the estimation of TSH. Based on the American Thyroid Association (ATA) guidelines, 159 (49.07%) subjects had TSH<2.5, while 76 (23.45%) subjects with TSH between 2.5–4.0 mU/L as per ATA definition were in the “at risk” category. Thirty subjects (9.26%) had TSH levels between 4.1–6.0 mU/L. A significant correlation was found between TSH and BMI and waist circumference, whereas a weak, non significant one was observed between TSH and waist hip ratio. A strong association between overweight (BMI>23) and elevated serum TSH concentration (TSH>4.1 mU/L) was also observed.
Conclusion: This spectrum of TSH levels highlighted a high prevalence of increased serum TSH levels in the population studied, a trend that was associated with obesity and various lipid abnormalities. Further population based studies are needed to correlate these findings with clinical parameters of hypothyroidism.

Keywords

Thyrotropin

Sub-clinical hypothy-roidism

Obesity

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