Latent Autoimmune Diabetes of Adults in Latakia, Syria


avatar AA Al-Farwi 1 , * , avatar MI Khayat 2 , avatar M Muhsen Al-Mehri 2

Department of Laboratory Medicine and bEndocrinology Division, Tishreen University, [email protected], Syria
Department of Laboratory Medicine and bEndocrinology Division, Tishreen University, Syria

how to cite: Al-Farwi A, Khayat M, Al-Mehri M. Latent Autoimmune Diabetes of Adults in Latakia, Syria. Int J Endocrinol Metab.8(1): 13-21.


This study aimed at assessing the frequency of latent autoimmune diabetes of adults (LADA) and its laboratory and clinical characteristics at the Diabetic Center of Latakia, Syria. Materials and Methods: Based on glutamic acid decarboxylase autoantibodies positivity, a population of 254 type 2 diabetic males and females, aged 35 to 75 years, were subdivided and studied in terms of the laboratory and clinical characteristics. Results: Glutamic acid decarboxylase autoantibodies (GADAs) were positive (GADA+) in 45 diabetic patients versus 209 type 2 diabetics with GADA negative (GADA-). In both subgroups, GADA+ and GADA-, no significant differences were observed in terms of anthropometric and clinical features except for body mass index (BMI) which was significantly lower in GADA+ subgroup (27.6±4.8 vs. 29.8±5.9; P= 0.02). Significant poor glycemic control was detected in terms of fasting blood sugar (FBS) (221.6±77.9 vs 182±66.7; P=0.001), glucosuria (60% vs. 41.6%; P=0.025), and ketonuria (22.2% vs. 3.8%; P<0.0001) in LADA patients (GADA+) versus type 2 diabetic patients (GADA-). By subdividing the studied sample into tertiles of type 2 diabetes, GADA- <5 IU/ml , GADA+ ≤50 IU/ml, and GADA+ >50 IU/ml, the tertile with high GADA titers (>50 IU/ml) presented significantly low BMI (P=0.012) and c-peptide levels (P<0.002) in comparison with type 2 and GADA≤ 50 IU/ml tertiles. Conclusion: Overall the prevalence of LADA was 17.7% in the type 2 diabetics studied. LADA patients showed similar laboratory and clinical features as type 2 diabetics, except for low BMI levels and poor glycemic control.

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