The Effect of Ginger (Zingiber officinale) on Oxidative Stress Status in the Small Intestine of Diabetic Rats

MH Khadem Ansari; M Karimipour; S Salami; A Shirpoor

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

Current Issue All Issues In Press Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

The Effect of Ginger (Zingiber officinale) on Oxidative Stress Status in the Small Intestine of Diabetic Rats

Author(s):

MH Khadem Ansari¹,

M Karimipour¹,

S Salami¹,

A Shirpoor^2,*

1Department of Biochemistry,Faculty of Medicine, Urmia University of Medical Sciences, IR.Iran

2Department of Physiology,Faculty of Medicine, Urmia University of Medical Sciences, ashirpoor@Yahoo.com, IR.Iran

International Journal of Endocrinology and Metabolism:Vol. 6, issue 3; 144-150

Article type:Research Article

Received:Jan 07, 2008

Accepted:Aug 28, 2008

How to Cite:MH Khadem AnsariM KarimipourS SalamiA ShirpoorThe Effect of Ginger (Zingiber officinale) on Oxidative Stress Status in the Small Intestine of Diabetic Rats.Int J Endocrinol Metab.6(3):144-150.

Abstract

Oxidative stress is produced under diabetic con-ditions and possibly causes various forms of tis-sue damage in patients with diabetes. The aim of the study was to investigate the effect of ginger on the occurrence of oxidative stress in the small intestine of diabetic rats. Materials and Methods: Twenty-four male Wis-tar rats were divided into three groups: control group, nontreated diabetic group, and diabetic group treated with ginger powder as 5% of their daily food. After 6 weeks, lipid peroxidation, protein oxidation, superoxide dismutase (SOD), and catalase levels of the small intestine were measured. Results: Diabetes caused significant increase of small intestine lipid peroxidation, protein oxida-tion, and SOD levels and decrease of catalase ac-tivity. Lipid peroxidation and protein oxidation were attenuated after consumption of ginger in the diabetic rats, and increased catalase activity. Conclusions: These findings indicate that ginger, as an oxidant, improves diabetes induced oxidative stress and its complications through prevention of lipid peroxidation and protein oxidation.

Keywords

Full Text

Full text is available in PDF

comments