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International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
Medroxyprogesterone Acetate and Progesterone, Used Short Term, Do not Adversely Affect Forearm Reactive Hyperemia in Postmenopausal Women on Estradiol Therapy
Authors
1Department of Obstetrics, Gynecology, and Womens Health, UMDNJ-New Jersey Medical School, [email protected], NJ
2Departments of Medicine and Preventive Medicine, Atherosclerosis Research Unit, USA
*Corresponding Author: Department of Obstetrics, Gynecology, and Womens Health, UMDNJ-New Jersey Medical School, [email protected], NJ. Email: [email protected]
Published online:Apr 30, 2008
Article type:Research Article
Received:Jun 30, 2007
Accepted:Jan 02, 2008
How to Cite:Cho M, Hodis H, Mack W, Roy S, Paulson R, et al. Medroxyprogesterone Acetate and Progesterone, Used Short Term, Do not Adversely Affect Forearm Reactive Hyperemia in Postmenopausal Women on Estradiol Therapy. Int J Endocrinol Metab. 2008;6(2):. doi:
Abstract
This study aimed at investigating whet-her oral medroxyprogesterone acetate (MPA) or micronized progesterone (P) combined with micronized estradiol (E2) adversely affect endothelial function in postmenopausal women. Materials and Methods: Randomized, double-blind, crossover trial of MPA or micronized P with oral E2 treatment in menopausal women. Result: Flow-mediated, endothelium-dependent vasodilation of the brachial artery was not sig-nificantly affected by short-term administration of E2 alone or E2 combined with cyclic MPA, or E2 combined with cyclic P. Conclusion: Short-term oral E2 treatment of postmenopausal women alone or with cyclic oral MPA or oral P did not affect flow-mediated en-dothelium-dependent vasodilation.
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Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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