Effect of Ghrelin on Plasma Concentration of Gonadotropins in the Female Sannan Goats

F Farifteh; H Khazali; M Emami

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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Effect of Ghrelin on Plasma Concentration of Gonadotropins in the Female Sannan Goats

Author(s):

F Farifteh^1,*,

H Khazali²,

M Emami³

1College of Biological Sciences, Shaheed Beheshti University, f.farifteh@yahoo.com, I.R.Iran

2College of Biological Sciences, Shaheed Beheshti University, I.R.Iran

3Center of Agricultural Institute of Yazd, I.R.Iran

International Journal of Endocrinology and Metabolism:Vol. 6, issue 1; 28-33

Article type:Research Article

Received:Dec 09, 2007

Accepted:Dec 16, 2008

How to Cite:F FariftehH KhazaliM EmamiEffect of Ghrelin on Plasma Concentration of Gonadotropins in the Female Sannan Goats.Int J Endocrinol Metab.6(1):28-33.

Abstract

Ghrelin is a 28 amino acid peptide which is secreted from the brain and the gastrointestinal system. Recent studies indicate that ghrelin negatively affects energy balance in most mammals. Based on its neuron distributions in hypothalamus, ghrelin coexists with many other neurons. Therefore, ghrelin controls different physiological actions on many different tracts; one of the physiological actions is its effect on gonadotropins secretions. The present investigation was carried out to analyze the potential involvement of ghrelin in the control of gonadotropin secretion. Materials and Methods: Forty female Sannan goats were randomly divided into two groups; each group received daily injections of either 1 or 2 mg ghrelin/kg of body weight (BW) into the jugular vein for ten days. Blood samples were collected every 30 minutes, for two hours after injection of ghrelin, for three days before first injection, till three days after last injection; the samples were assayed for plasma FSH and LH concentration by the Radioimmunoassay (RIA) technique. Results: Injections of 1 and 2 mg ghrelin/kg BW decreased the mean plasma concentration of LH throughout the injection period in all animals in the two groups. The results indicated that ghre-lin significantly decreased mean plasma concen-tration of LH in the female Sannan goats (p<0.01); it however had no significant effect on the mean plasma concentration of FSH. Conclusions: It was concluded that while ghrelin has no effect in the secretion of FSH, it does have an inhibitory effect on LH.

Keywords

Ghrelin

Follicle stimulating hormone

Luteinizing hormone

Sannan goat

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