The Association of Carotid Intima-Media Thickness and Postprandial Dyslipidemia in Patients with Type 2 Diabetes

ME Khamseh; K Soltani; J Rafiee; A Mokhber; H Baradaran

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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The Association of Carotid Intima-Media Thickness and Postprandial Dyslipidemia in Patients with Type 2 Diabetes

Author(s):

ME Khamseh¹,

K Soltani²,

J Rafiee¹,

A Mokhber¹,

H Baradaran^3,*

1Medical Education & Development Centre, Iran University of Medical Sciences, I.R.Iran

2Medical Education & Development Centre, Iran University of Medical Sciences, Tehran, I.R.Iran

3Medical Education & Development Centre, Iran University of Medical Sciences, baradaran@iums.ac.ir, I.R.Iran

International Journal of Endocrinology and Metabolism:Vol. 5, issue 1; 5-8

Article type:Research Article

Received:Sep 06, 2006

Accepted:Dec 06, 2006

How to Cite:ME KhamsehK SoltaniJ RafieeA MokhberH BaradaranThe Association of Carotid Intima-Media Thickness and Postprandial Dyslipidemia in Patients with Type 2 Diabetes.Int J Endocrinol Metab.5(1):5-8.

Abstract

This research aimed at investigating the correla-tion between postprandial dyslipidemia and ca-rotid intimae-media thickness in people with dia-betes. Materials and Methods: In 28 diabetic patients and 22 age and sex- matched healthy adults, the carotid intimae-media thickness was measured using Doppler ultrasound. Blood glucose, total cholesterol, triglycerides, LDL and HLD choles-terol level were measured after overnight fasting and again 4 hours after a standard high-fat meal. Results: The carotid intimae-media thickness of diabetic patients was greater than normal sub-jects (0.96±0.29 mm vs. 0.75±0.17 mm, respec-tively p=0.008). Diabetic patients showed post-prandial hypertriglyceridemia (P=0.03). In pa-tients with fasting hyperglycemia and postpran-dial hypertriglyceridemia, carotid intimae-media thickness was greater than in patients with nor-mal levels (p=0.04 and p=0.03 respectively). Conclusion: Postprandial hypertriglyceridemia and fasting hyperglycemia may be an independ-ent risk factor for early atherosclerosis and macrovascular disease in individuals with type 2 diabetes.

Keywords

Carotid intima-media thickness (IMT)

Type 2 Diabetes

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