Liver Cholestasis in Thyrotoxicosis: a Case Report

GK Sjberg; P Katzman; B Hallengren

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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Liver Cholestasis in Thyrotoxicosis: a Case Report

Author(s):

GK Sjberg^1,*,

P Katzman²,

B Hallengren²

1Departments of Medicine Lund University Hospital,Endocrinology, Malm University Hospital, klas.sjoberg@med.lu.se, Sweden

2Department of Endocrinology, Lund University Hospital, Sweden

International Journal of Endocrinology and Metabolism:Vol. 5, issue 1; 44-48

Article type:Case Report

Received:Feb 19, 2006

Accepted:Dec 12, 2006

How to Cite:GK SjbergP KatzmanB HallengrenLiver Cholestasis in Thyrotoxicosis: a Case Report.Int J Endocrinol Metab.5(1):44-48.

Abstract

Thyrotoxicosis is often associated with liver and malfunction, often for long durations; some-times the liver function is substantially impaired for a longer period of time. The exact nature however of the relation between hepatic dys-function and thyrotoxicosis remains obscure. Presented here is a case report of liver cholesta-sis as a complication of thyrotoxicosis. Materials and Method: A previously healthy 41-year-old man with thyrotoxicosis complicated with liver cholestasis is discussed. Results: The patient reported had a typical thyro-toxicosis but following radioiodine treatment concomitantly developed jaundice and severe pruritus that required several weeks of treatment in hospital and took several months to disap-pear. In this report the therapeutical considera-tions as well as the pathogenetic possibilities are reviewed. Conclusion: The association observed is not common but may be severe and should be con-sidered in any case of thyrotoxicosis where a cholestatic condition develops.

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