Protein Tyrosine Phosphatase-Like Protein Ia2 Antibodies and Glutamic Acid Decarboxylase 65 Antibodies (GADA) are not Associated With Sarcoidosis

I Konstantinos; Sundkvist Gran; Borg Henrik; Hallengren Bengt

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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Protein Tyrosine Phosphatase-Like Protein Ia2 Antibodies and Glutamic Acid Decarboxylase 65 Antibodies (GADA) are not Associated With Sarcoidosis

Author(s):

I Papadopoulos Konstantinos^1,*,

Sundkvist Gran²,

Borg Henrik²,

Hallengren Bengt²

1Department of Endocrinology, University of Lund, Malm University Hospital, S-205 02, kostasp@truemail.co.th, Sweden

2Department of Endocrinology, University of Lund, Malm University Hospital, S-205 02, Sweden

International Journal of Endocrinology and Metabolism:Vol. 4, issue 3; 147-150

Article type:Research Article

Received:Jan 20, 2005

Accepted:Aug 17, 2006

How to Cite:I Papadopoulos KonstantinosSundkvist GranBorg HenrikHallengren BengtProtein Tyrosine Phosphatase-Like Protein Ia2 Antibodies and Glutamic Acid Decarboxylase 65 Antibodies (GADA) are not Associated With Sarcoidosis.Int J Endocrinol Metab.4(3):147-150.

Abstract

The existence of an association between glu-tamic acid decarboxylase 65 antibodies (GADA) and/or IA2 antibodies and sarcoidosis was evaluated. Materials and Methods: 78 patients with docu-mented sarcoidosis, divided according to the presence (N=37) or absence (N=41) of autoim-mune manifestations were evaluated for GADA and IA2 antibodies using, a radioligand assay with human recombinant 35S-labeled GAD65 and IA2 respectively. Results: Two patients with GADA (2.6%) and one (1.3%) with IA2ab, both in the group of pa-tients with autoimmunity associated sarcoidosis were found. The GADA positive patient had manifest Type 1 diabetes that succeeded sarcoi-dosis. IA2 ab-positivity was seen among patients with isolated sarcoidosis. GADA and IA2ab fre-quencies were not increased compared to refer-ence subjects (2-3%). Conclusions: No clear association between sar-coidosis and GADA and/or IA2ab was found. In patients with sarcoidosis, GADA seem to be as-sociated with type 1 diabetes or other autoim-mune manifestations rather than with sarcoido-sis per se.

Keywords

Sarcoidosis

Autoimmunity

Islet cell antibodies

Glutamic acid decarboxylase

IA2

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