Protein Tyrosine Phosphatase-Like Protein Ia2 Antibodies and Glutamic Acid Decarboxylase 65 Antibodies (GADA) are not Associated With Sarcoidosis

authors:

avatar I Papadopoulos Konstantinos 1 , * , avatar Sundkvist Gran 2 , avatar Borg Henrik 2 , avatar Hallengren Bengt 2

Department of Endocrinology, University of Lund, Malm University Hospital, S-205 02, kostasp@truemail.co.th, Sweden
Department of Endocrinology, University of Lund, Malm University Hospital, S-205 02, Sweden
International Journal of Endocrinology and Metabolism: Vol.4, issue 3; 147-150
article type: Original Article
received: January 20, 2005
accepted: August 17, 2006

How To Cite Konstantinos I, Gran S, Henrik B, Bengt H. Protein Tyrosine Phosphatase-Like Protein Ia2 Antibodies and Glutamic Acid Decarboxylase 65 Antibodies (GADA) are not Associated With Sarcoidosis. Int J Endocrinol Metab. 2006;4(3): 147-150. 

Abstract

The existence of an association between glu-tamic acid decarboxylase 65 antibodies (GADA) and/or IA2 antibodies and sarcoidosis was evaluated. Materials and Methods: 78 patients with docu-mented sarcoidosis, divided according to the presence (N=37) or absence (N=41) of autoim-mune manifestations were evaluated for GADA and IA2 antibodies using, a radioligand assay with human recombinant 35S-labeled GAD65 and IA2 respectively. Results: Two patients with GADA (2.6%) and one (1.3%) with IA2ab, both in the group of pa-tients with autoimmunity associated sarcoidosis were found. The GADA positive patient had manifest Type 1 diabetes that succeeded sarcoi-dosis. IA2 ab-positivity was seen among patients with isolated sarcoidosis. GADA and IA2ab fre-quencies were not increased compared to refer-ence subjects (2-3%). Conclusions: No clear association between sar-coidosis and GADA and/or IA2ab was found. In patients with sarcoidosis, GADA seem to be as-sociated with type 1 diabetes or other autoim-mune manifestations rather than with sarcoido-sis per se.

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