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International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
Protein Tyrosine Phosphatase-Like Protein Ia2 Antibodies and Glutamic Acid Decarboxylase 65 Antibodies (GADA) are not Associated With Sarcoidosis
Authors
1Department of Endocrinology, University of Lund, Malm University Hospital, S-205 02, [email protected], Sweden
2Department of Endocrinology, University of Lund, Malm University Hospital, S-205 02, Sweden
*Corresponding Author: Department of Endocrinology, University of Lund, Malm University Hospital, S-205 02, [email protected], Sweden. Email: [email protected]
Published online:Jul 31, 2006
Article type:Research Article
Received:Jan 20, 2005
Accepted:Aug 17, 2006
How to Cite:Konstantinos I, Gran S, Henrik B, Bengt H. Protein Tyrosine Phosphatase-Like Protein Ia2 Antibodies and Glutamic Acid Decarboxylase 65 Antibodies (GADA) are not Associated With Sarcoidosis. Int J Endocrinol Metab. 2006;4(3):. doi:
Abstract
The existence of an association between glu-tamic acid decarboxylase 65 antibodies (GADA) and/or IA2 antibodies and sarcoidosis was evaluated. Materials and Methods: 78 patients with docu-mented sarcoidosis, divided according to the presence (N=37) or absence (N=41) of autoim-mune manifestations were evaluated for GADA and IA2 antibodies using, a radioligand assay with human recombinant 35S-labeled GAD65 and IA2 respectively. Results: Two patients with GADA (2.6%) and one (1.3%) with IA2ab, both in the group of pa-tients with autoimmunity associated sarcoidosis were found. The GADA positive patient had manifest Type 1 diabetes that succeeded sarcoi-dosis. IA2 ab-positivity was seen among patients with isolated sarcoidosis. GADA and IA2ab fre-quencies were not increased compared to refer-ence subjects (2-3%). Conclusions: No clear association between sar-coidosis and GADA and/or IA2ab was found. In patients with sarcoidosis, GADA seem to be as-sociated with type 1 diabetes or other autoim-mune manifestations rather than with sarcoido-sis per se.
Copyright
© 2006, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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