Peripheral Nerve Function in Subclinical Hypothyroidism: A Case-Control Study

1Department of Physical Medicine and Rehabilitation, Endocrinology and Metabolism, and Community-Based Medicine, Tabriz University of Medical Sciences, [email protected], IR.Iran

2Department of Physical Medicine and Rehabilitation, Endocrinology and Metabolism, and Community-Based Medicine, Tabriz University of Medical Sciences, IR.Iran

International Journal of Endocrinology and Metabolism:Vol. 4, issue 2; 78-83

Published online:Apr 30, 2006

Article type:Research Article

Received:Jan 08, 2005

Accepted:Dec 19, 2005

How to Cite:Jalilzadeh S, Bahrami A, Eftekharosadat B, Mobasseri M, Pezeshki Z. Peripheral Nerve Function in Subclinical Hypothyroidism: A Case-Control Study. Int J Endocrinol Metab. 2006;4(2):. doi:

Abstract

Peripheral nerve dysfunction is a well docu-mented feature of clinical hypothyroidism. Only a few studies have evaluated the functional al-terations in central and peripheral nervous sys-tems in subjects with subclinical hypothyroid-ism and results obtained have been controver-sial. The purpose of the present study was to in-vestigate the effects of subclinical hypothyroid-ism on peripheral nerve function. Materials and Methods: Twenty-eight individu-als (25 females and 3 males) with subclinical hy-pothyroidism (defined biochemically as high se-rum TSH with simultaneously normal serum free T4) as the study group and 30 age and sex matched subjects (27 females and 3 males) with normal thyroid function tests as the control group were enrolled into the study. None of the patients or controls had history of diabetes mel-litus, neuromuscular, metabolic, vasculitic or rheumatologic diseases or were taking medica-tions that may alter central or peripheral nerve function. Standard electrodiagnostic methods were used to study motor parameters including motor nerve conduction velocity, distal motor la-tencies, compound muscle action potential am-plitude from median, ulnar, tibial and deep per-oneal nerves, minimal-F-response from tibial, median and ulner nerves and sensory parameters including sensory nerve conduction velocity, sensory nerve action potential amplitude and distal sensory latencies from median, ulnar and sural nerves. In all patients and controls, values were obtained from both right and left sides. Values from patients were compared with those of controls by unpaired student's t-test. Results: Motor and sensory nerve function val-ues obtained from this electrophysiological study yielded no significant differences between patients with subclinical hypothyroidism and those with normal thyroid function. Conclusion: The results of this study show that there are no significant alterations in peripheral nerve function in patients with subclinical hypo-thyroidism.

Keywords

Subclinical hypothyroidism

Periph-eral neuropathy

Electrophysiologic parameters

Full Text

Full text is available in PDF

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 5 days ago
Scopus by Title: 0
Last Update: 5 days ago
Scopus by Title (Ref): 6
Last Update: 5 days ago
CrossRef: 0
Last Update: 1 day ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

SH Jalilzadeh:[PubMed][Scholar]
A Bahrami:[PubMed][Scholar]
B Eftekharosadat:[PubMed][Scholar]
M Mobasseri:[PubMed][Scholar]
Z Pezeshki:[PubMed][Scholar]

Research Institute for Endocrine Sciences

Outlines

Peripheral Nerve Function in Subclinical Hypothyroidism: A Case-Control Study

Abstract

Full Text

Last Update: 5 days ago

Last Update: 5 days ago

Last Update: 5 days ago

Last Update: 1 day ago