Adrenal Myelolipoma: Profile of Six Patients With a Brief Review of Literature

A Bhansali; R Dash; S Singh; A Behra; P Singh; B Radotra

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

Current Issue All Issues In Press Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Adrenal Myelolipoma: Profile of Six Patients With a Brief Review of Literature

Author(s):

A Bhansali¹,

R J Dash^2,*,

S K Singh¹,

A Behra¹,

P Singh¹,

B D Radotra¹

1Departments of Endocrinology, Postgraduate Institute of Medical Education and Research, India

2Departments of Endocrinology, Postgraduate Institute of Medical Education and Research, rjdash@rediffmail.com, India

International Journal of Endocrinology and Metabolism:Vol. 1, issue 1; 33-40

Article type:Case Report

Received:Jan 01, 2002

Accepted:Feb 20, 2003

How to Cite:A BhansaliR J DashS K SinghA BehraP SinghB D Radotraet al.Adrenal Myelolipoma: Profile of Six Patients With a Brief Review of Literature.Int J Endocrinol Metab.1(1):33-40.

Abstract

Six patients with adrenal myelolipoma (AML) are reported. They included 3 men and 3 women with mean age (+ SD) of 42.3 + 10.9 yrs ranging from 26 to 60 yrs. Four patients were symptomatic, while the other 2 had no symptoms. Detection of AML was ‘incidental’ in 4 patients while being investigated for non-adrenal symptoms (pain abdomen in 2 and work-up for renal disease in 2), while the remaining 2 patients, one (#5) with congenital adrenal hyperplasia due to 21 alpha-hydroxylase deficiency had myelolipomatous alterations in the adrenal gland and the other (#6) had detection of AML during work-up for hypertension. All patients were obese (BMI > 27), four were hypertensive and one had type 2 diabetes. Imaging was suggestive of AML in five of them. However, in one case radiological diagnosis of angiomyolipoma of the kidney was considered. Interestingly, the right adrenal was involved in five of them. Four patients underwent adrenalectomy in view of symptoms and size of the mass, while the other 2 are under follow-up. Cyto/histopathology was consistent with AML in all these patients. However, in one case myelolipomatous alterations were noted in the background of adreno-cortical tumor. No recurrence or alterations in tumor size was noted during the follow-up period ranging from 6 months to 4 years. A brief review of literature is also presented.

Keywords

Adipose tissue

Adrenal neoplasm

Hematopoiesis

Full Text

Full text is available in PDF

comments