A Preventive Trial of Short-Term Immunosuppressive Therapy in Postpartum Thyroid Dysfunction

H Tada; Y Hidaka; Y Izumi; T Takano; Y Nakata; K Tatsumi; N Amino

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

Current Issue All Issues In Press Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

A Preventive Trial of Short-Term Immunosuppressive Therapy in Postpartum Thyroid Dysfunction

Author(s):

H Tada¹,

Y Hidaka¹,

Y Izumi¹,

T Takano¹,

Y Nakata¹,

K Tatsumi¹,

N Amino^2,*

1Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Japan

2Department of Laboratory Medicine, Osaka University Graduate School of Medicine, [email protected], Japan

International Journal of Endocrinology and Metabolism:Vol. 1, issue 2; 48-54

Published online:Jul 31, 2003

Article type:Research Article

Received:Jan 01, 2003

Accepted:May 01, 2003

How to Cite:Tada H, Hidaka Y, Izumi Y, Takano T, Nakata Y, et al. A Preventive Trial of Short-Term Immunosuppressive Therapy in Postpartum Thyroid Dysfunction. Int J Endocrinol Metab. 2003;1(2):. doi:

Abstract

Autoimmune diseases, once developed, are often hard to control and thus prevention of disease development is obviously of great importance. Postpartum onset of autoimmune diseases, especially autoimmune thyroid disease, is frequently observed and postpartum hypothyroidism is a good candidate for investigation of prediction and a trial of prevention of disease development.
Materials and Methods: In order to clarify the method of prediction of postpartum onset of hypothyroidism, 9 patients who had had previous episodes of postpartum hypothyroidism and high titers (more than 5 x 103) of anti-thyroid microsomal antibodies were examined during the postpartum period of their current pregnancies. Thyroid function, size of goiter and titer of anti-microsomal antibodies were observed every month for 12 months after delivery. The other two patients, who were expected to develop postpartum hypothyroidism after present parturition and had high anti-thyroid microsomal antibody titers of more than 5 x 103, were treated with short-term glucocorticoid therapy.
Results: All 9 patients, who had previous postpartum transient hypothyroidism and had had high anti-thyroid microsomal antibodies, developed recurrence of postpartum hypothyroidism at almost the same postpartum time. A shortterm glucocorticoid therapy was tried for two other cases who were expected to have recurrence of postpartum hypothyroidism. In the first case, occurrence of postpartum hypothyroidism was delayed by 2 months and peak value of TSH was lower than that of the previous episode. In the second case, duration and dose of predonisolone was doubled and development of postpar- tum hypothyroidism was successfully prevented.
Conclusion: Postpartum recurrence of hypothyroidism was predicted in patients who had previous episodes of postpartum transient hypothyroidism and higher titers of anti-thyroid microsomal antibodies. The short-term predonisolone therapy successfully prevented postpartum development of hypothyroidism in one case.

Keywords

Postpartum thyroiditis

Prevention

Glucocorticoid therapy

Postpartum hypothyroidIsm

Full Text

Full text is available in PDF

Prevalence of Postpartum Thyroiditis in the Eastern Regions of Iran

Robab Bigom Aboutorabi,

Mohammad Khajeh Daluee,

Hosein Ayatollahi,

Haleh Rokni

Aboutorabi RB, Khajeh Daluee M, Ayatollahi H, Rokni H. Prevalence of Postpartum Thyroiditis in the Eastern Regions of Iran. Int J Endocrinol Metab. 2011;9(4):. doi: https://doi.org/10.5812/Kowsar.1726913X.2294

30

Apr

2009

Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran

M a Taghavi,

N b Saghafi,

S b Shirin

Taghavi M, Saghafi N, Shirin S. Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran. Int J Endocrinol Metab. 2009;7(2):. doi:

31

Jan

2007

Subclinical Hypothyroidism

S Kalantari

Kalantari S. Subclinical Hypothyroidism. Int J Endocrinol Metab. 2007;5(1):. doi:

30

Jan

2016

Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol

Sima Nazarpour,

Fahimeh Ramezani Tehrani,

Masoumeh Simbar,

Maryam Tohidi,

Fereidoun Azizi

Nazarpour S, Ramezani Tehrani F, Simbar M, Tohidi M, Azizi F. Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol. Int J Endocrinol Metab. 2016;14(1):e33477. doi: https://doi.org/10.5812/ijem.33477

1

Oct

2014

Thyroid Function in Pregnancy and Its Influences on Maternal and Fetal Outcomes

Forough Saki,

Mohammad Hossein Dabbaghmanesh,

Seyede Zahra Ghaemi,

Sedighe Forouhari,

Gholamhossein Ranjbar Omrani,

Marzie Bakhshaieshkaram

Saki F, Dabbaghmanesh MH, Ghaemi SZ, Forouhari S, Ranjbar Omrani G, et al. Thyroid Function in Pregnancy and Its Influences on Maternal and Fetal Outcomes. Int J Endocrinol Metab. 2014;12(4):e19378. doi: https://doi.org/10.5812/ijem.19378

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 2 weeks ago
Scopus by Title: 0
Last Update: 2 weeks ago
Scopus by Title (Ref): 4
Last Update: 2 weeks ago
CrossRef: 0
Last Update: 3 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

H Tada:[PubMed][Scholar]
Y Hidaka:[PubMed][Scholar]
Y Izumi:[PubMed][Scholar]
T Takano:[PubMed][Scholar]
Y Nakata:[PubMed][Scholar]
K Tatsumi:[PubMed][Scholar]
N Amino:[PubMed][Scholar]

Research Institute for Endocrine Sciences

Outlines

A Preventive Trial of Short-Term Immunosuppressive Therapy in Postpartum Thyroid Dysfunction

Abstract

Full Text

Similar Articles

Prevalence of Postpartum Thyroiditis in the Eastern Regions of Iran

Outcome of Thyroid Dysfunction in Pregnancy in Mashhad, Iran

Subclinical Hypothyroidism

Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol

Thyroid Function in Pregnancy and Its Influences on Maternal and Fetal Outcomes

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 3 days ago