A Novel Mutation of SLC26A4 Gene In an Iranian Family with Pendred Syndrome

authors:

avatar K Kahrizi 1 , avatar C Nishimura 2 , avatar A Naghavi 1 , avatar Y Riazalhosseini 1 , avatar RJH Smith 2 , avatar H Najmabadi 3 , *

Genetic Research Center, University of Social Walfare and Rehabilitation Sciences, Iran
Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, University of Iowa, IA, USA
Genetic Research Center, University of Social Walfare and Rehabilitation Sciences, hnajm@mavara.com, Iran
International Journal of Endocrinology and Metabolism: Vol.3, issue 2; 104-108
article type: Original Article
received: January 1, 2004
accepted: March 1, 2005

how to cite: Kahrizi K, Nishimura C, Naghavi A, Riazalhosseini Y, Smith R, et al. A Novel Mutation of SLC26A4 Gene In an Iranian Family with Pendred Syndrome. Int J Endocrinol Metab. 2005;3(2): 104-108. 

Abstract

In the diagnosis of Pendred syndrome, assessment of individuals by molecular analysis of the SLC26A4 gene is recommended. Here we report a novel mutation in the SLC26A4 gene as revealed by denaturing high performance liquid chromatography (DHPLC) and DNA sequencing of the entire coding region of the SLC26A4 gene in five members of an Iranian family affected with Pendred syndrome. This is the first report of the molecular investigation of Pendred syndrome in Iran and the first report of the R79X mutation.

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