Propylthiouracil Induced ANCA Positive Vasculitis: a Case Report

authors:

avatar Khanolkar MP 1 , avatar Owen PJD 1 , avatar Lazarus JH 2 , *

Department of Medicine, University of Wales College of Medicine, UK
Department of Medicine, University of Wales College of Medicine, lazallls@cf.ac.uk, UK

how to cite: MP K, PJD O, JH L. Propylthiouracil Induced ANCA Positive Vasculitis: a Case Report. Int J Endocrinol Metab. 2004;2(1): 47-50. 

Abstract

Anti-thyroid drugs, methimazole, carbimazole and propylthiouracil are commonly prescribed for the treatment of hyperthyroidism due to Graves' disease_ We present here the report of a Caucasian patient with Graves' disease who developed ANCA positive propylthiouracil induced vasculitis_ The episode was characterised by a vasculitic skin rash associated with polyarthralgia but no renal involvement_ While carbimazole/ methimazole has a lower incidence of reported ANCA positive side effects than PTU, the use of the latter in pregnancy may still be considered as reasonable because the immunosuppression of pregnancy may prevent the appearance of immune problems.

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