Vascular Cell Adhesion Molecule-l (VCAM-l) in Graves' Disease: Its Association to Thyroid Status and Thyroid Receptor Stimulating Antibodies

Wan Nazaimoon WM; Ismail IS; Tan HJ; Kamaruddin NA; Khalid AK

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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Vascular Cell Adhesion Molecule-l (VCAM-l) in Graves' Disease: Its Association to Thyroid Status and Thyroid Receptor Stimulating Antibodies

Author(s):

Wan Nazaimoon WM^1,*,

Ismail IS²,

Tan HJ³,

Kamaruddin NA³,

Khalid AK³

1Institute for Medical Research, nazaimoon@imr.gov.my, Malaysia

2University Malaya Medical Center, Malaysia

3Faculty of Medicine, Universiti Kebangsaan, Malaysia

International Journal of Endocrinology and Metabolism:Vol. 2, issue 2; 66-73

Published online:Jan 01, 2004

Article type:Research Article

How to Cite:Wan Nazaimoon WMIsmail ISTan HJKamaruddin NAKhalid AKVascular Cell Adhesion Molecule-l (VCAM-l) in Graves' Disease: Its Association to Thyroid Status and Thyroid Receptor Stimulating Antibodies.Int J Endocrinol Metab.2(2):66-73.

Abstract

Materials and Methods:

Patients were given fixed daily dose of 20 mg carbimazole for 3 months and blood samples were collected at baseline and end of the study. Thirty-eight patients were recruited from the Endocrine Clinic, Hospital Universiti Kebangsaan Malaysia, consisting of 26 females and 12 males, age ranging from 16 to 65 years. Blood samples collected before and at end of study were analysed for TSH, Free TJ, Free T4J thyroid receptor stimulating antibodies (TRAb), sVCAM-1, sICAM-1 and lL-6.

Results:

TRAb level of ?10 to U/L was taken to be negative, while TRAb level of >10 U/L was considered as positive. Twenty-six patients (68%) were TRAb positive (TRAb+) and 12 patients (30%) were TRAb negative (TRAb-). Median TRAb in TRAb+ patients was 23 UIL at baseline, declining to 16.7 U/L (p

Conclusion:

Compared to other inflammatory markers, sVCAM-l showed significant correlation to thyrOid stimulating antibodies and was most sensitive to changes in thyroid status. The significance of these findings in relation to Graves' disease warrants further investigation.

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