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International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
hCG, the Centerpiece of Life and Death
Authors
1USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, USA
*Corresponding Author: Laurence A. Cole, USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87109, USA. Tel/Fax:+1-5052723576, E-mail: Email: [email protected]
Published online:Apr 30, 2011
Article type:Review Article
Received:Feb 05, 2011
Accepted:Mar 20, 2011
How to Cite:A. Cole L. hCG, the Centerpiece of Life and Death. Int J Endocrinol Metab. 2011;9(2):. doi: https://doi.org/10.5812/kowsar.1726913X.3398
Abstract
hCG is a generic name for 5 biologically active molecules that share a common α and ß-subunit amino acid sequence. These 5 molecules have key biological function in human pregnancy and human cancer. This review examines these molecule in detail. These 5 molecules, hCG, sulfated hCG, hyperglycosylated hCG, hCG free ß and hyperglycosylated free ß are produced by placental syncytiotrophoblast cells and pituitary gonadotrope cells (group 1), and by placental cytotrophoblast cells and human malignancies (group 2). Group 1 molecules are both hormones that act on the hCG/LH receptor. These molecules are central to human menstrual cycle and human pregnancy. Group 2 molecules are autocrines that act by antagonizing a TGFß receptor. These molecules are critical to all advanced malignancies.The hCG groups are molecules critical to both the molecules of pregnancy or human life, and to the advancement of cancer, or human death.
Copyright © 2011, Kowsar M.P.Co. All rights reserved.
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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