The Influence of Supplemental Vitamin C on Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus

B Forghani; V Goharian; N Kasaeeian; M Amini

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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The Influence of Supplemental Vitamin C on Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus

Author(s):

B Forghani^1,*,

V Goharian¹,

N Kasaeeian¹,

M Amini¹

1Endocrine Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, I.R.Iran

International Journal of Endocrinology and Metabolism:Vol. 1, issue 2; e94488

Published online:Jun 30, 2003

Article type:Research Article

Received:May 26, 2019

Accepted:Jun 30, 2003

How to Cite:B ForghaniV GoharianN KasaeeianM AminiThe Influence of Supplemental Vitamin C on Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus.Int J Endocrinol Metab.1(2):e94488.

Abstract

There is evidence implying the influence of vitamin C on prevention of hemoglobin glycation. The aim of the present study was to investigate the effect of vitamin C on the level of glycosylated hemoglobin (HbAlc) in patients with type 2-diabetes.
Materials and Methods: 18 patients with type 2 diabetes (14 females, 4 males) were enrolled in a
clinical trial study. 1000 mg of supplemental vitamin C (divided into 4 doses) per day was given to the subjects for 6 weeks. Body mass index (BMI), a 3-day diet recall, fasting plasma glucose and glycosylated hemoglobin were measured before and after the administration of supplemental vitamin C. Data were analyzed by paired t-test.
Results: Body weight and BMI were slightly higher at the end of study, as compared to before. Glycosylated hemoglobin level decreased significantly at the end of study 1l.8±1.48 vs, 10.2±1.28%, (p<0.015). Fasting plasma glucose did not change.
Conclusion: Our findings indicate that vitamin C as a result of its structural similarity to glucose can compete with it to reduce hemoglobin glycosylation in patients with type 2-diabetes.

Keywords

Vitamin C

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