The Influence of Supplemental Vitamin C on Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus


avatar B Forghani 1 , * , avatar V Goharian 1 , avatar N Kasaeeian 1 , avatar M Amini 1

Endocrine Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, I.R.Iran

how to cite: Forghani B, Goharian V, Kasaeeian N, Amini M. The Influence of Supplemental Vitamin C on Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus. Int J Endocrinol Metab. 2003;1(2):e94488.


There is evidence implying the influence of vitamin C on prevention of hemoglobin glycation. The aim of the present study was to investigate the effect of vitamin C on the level of glycosylated hemoglobin (HbAlc) in patients with type 2-diabetes. 
Materials and Methods: 18 patients with type 2 diabetes (14 females, 4 males) were enrolled in a 
clinical trial study. 1000 mg of supplemental vitamin C (divided into 4 doses) per day was given to the subjects for 6 weeks. Body mass index (BMI), a 3-day diet recall, fasting plasma glucose and glycosylated hemoglobin were measured before and after the administration of supplemental vitamin C. Data were analyzed by paired t-test. 
Results: Body weight and BMI were slightly higher at the end of study, as compared to before. Glycosylated hemoglobin level decreased significantly at the end of study 1l.8±1.48 vs, 10.2±1.28%, (p<0.015). Fasting plasma glucose did not change. 
Conclusion: Our findings indicate that vitamin C as a result of its structural similarity to glucose can compete with it to reduce hemoglobin glycosylation in patients with type 2-diabetes.


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