Pharmacotherapy Of Type 2 Diabetes – The Future

AP Abhay; DM Ravichand; V Seshayamma; P Satish chandran

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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Pharmacotherapy Of Type 2 Diabetes – The Future

Author(s):

AP Abhay^1,*,

DM Ravichand¹,

V Seshayamma¹,

P Satish chandran¹

1Department of Pharmacology, Osmania Medical College, Hyderabad – 500 095, India

International Journal of Endocrinology and Metabolism:Vol. 4, issue 3; e94594

Published online:Jan 31, 2006

Article type:Research Article

Received:May 28, 2019

Accepted:Jan 31, 2006

How to Cite:AP AbhayDM RavichandV SeshayammaP Satish chandranPharmacotherapy Of Type 2 Diabetes – The Future.Int J Endocrinol Metab.4(3):e94594.

Abstract

In the last decade, explosion in therapeutic op-tions for management of type 2 diabetes mellitus (DM) have increased significantly with advances in recombinant DNA technology, molecular bi-ology, clinical chemistry; analogs of insulin have replaced animal insulin, and may displace NPH, regular lente, ultra lente, insulin’s. Analogs such as insulin glargine, insulin lispro, insulin aspart, and insulin glulisine are becoming mainstream therapy for even type 2 DM Besides oral hypo-glycemic agents i.e., sulphonyl ureas, biguanides and thiazolidinediones, newer insulin analogs and non-insulin antidiabetics are in various stages of development. Incretin analogs, amylin analogs, combined P PAR-γ and α agonists, islet-neogenesis gene-associated protein (INGAP) are most prominent amongst these. This review fo-cuses on pramlintide, an amylin analog, GLP-1 agonists and exenatide, an exendin 4 analog re-cently approved for use in type 2 diabetes by US FDA. Newer insulin delivery methods and drugs have also been reviewed.

Keywords

Pharmacotherapy

Diabetes

Insulin

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