Objectives: The purposes of the current study were to investigate the effect of chronic physical exercise training on (a) heart- and gastrocnemius-muscle ABCA1 expression and (b) plasma apolipoprotein-A (apo-A) and pre-β-HDL concentrations.
Materials and Methods: 10 adult male Wistar rats (12 to 14 weeks old, 200 to 220 g) were divided into control (n = 5) and training (n = 5) groups. The training group was exercised on a motor-driven treadmill at 25 m/min (0% grade) for 60 min/day, 5 days/week, for 12 weeks. Rats were sacrificed 48 h after the last exercise session. A portion of the heart and gastrocnemius muscles were excised, immediately cleaned, washed in ice-cold saline, and frozen in liquid nitrogen for extraction of ABCA1 mRNA. Unpaired t student tests were used to analyze the data. Results: Higher and significant ABCA1 expression, plasma apo-A, and pre-β-HDL concentrations were found in the trained rats than in the control group.
Conclusions: The results indicate that exercise-training-induced ABCA1 expression in heart and gastrocnemius muscles was accompanied with higher plasma apo-A and pre-β-HDL concentrations. This might reinforce the initiation of reverse cholesterol transport process.
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